Faculty of Pharmacy
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Item type:Publication, Critical development by design of a rugged HPLC-MS/MS method for direct determination of ibuprofen enantiomers in human plasma(Elsevier BV, 2015-06); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CHEMOMETRIC APPROACH FOR OPTIMIZATION OF HILIC METHOD FOR SIMULTANEOUS DETERMINATION OF IMIPENEM AND CILASTATIN SODIUM IN POWDER FOR INJECTION(Informa UK Limited, 2013-12-11); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, High-Throughput HPLC-MS/MS Method for Quantification of Ibuprofen Enantiomers in Human Plasma: Focus on Investigation of Metabolite Interference(Oxford University Press (OUP), 2016-10-12); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Headspace screening: A novel approach for fast quality assessment of the essential oil from culinary sage(Elsevier BV, 2016-07); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, An experimental design approach in optimization of an extraction procedure for AAS determination of Ca, Mg, Zn, Cu and Fe in multimineral dietary supplements(2018-09); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Development and optimization of a generic HPLC method for the simultaneous determination of common ingredients in multi component cough and cold oral drug products using chemometrics(Macedonian Pharmaceutical Association, 2018); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Implementation of quality by design principles in the development of microsponges as drug delivery carriers: Identification and optimization of critical factors using multivariate statistical analyses and design of experiments studies(Elsevier BV, 2015-07-15); ; ; Slavevska Raicki, RenataMicrosponges drug delivery system (MDDC) was prepared by double emulsion-solvent-diffusion technique using rotor-stator homogenization. Quality by design (QbD) concept was implemented for the development of MDDC with potential to be incorporated into semisolid dosage form (gel). Quality target product profile (QTPP) and critical quality attributes (CQA) were defined and identified, accordingly. Critical material attributes (CMA) and Critical process parameters (CPP) were identified using quality risk management (QRM) tool, failure mode, effects and criticality analysis (FMECA). CMA and CPP were identified based on results obtained from principal component analysis (PCA-X&Y) and partial least squares (PLS) statistical analysis along with literature data, product and process knowledge and understanding. FMECA identified amount of ethylcellulose, chitosan, acetone, dichloromethane, span 80, tween 80 and water ratio in primary/multiple emulsions as CMA and rotation speed and stirrer type used for organic solvent removal as CPP. The relationship between identified CPP and particle size as CQA was described in the design space using design of experiments - one-factor response surface method. Obtained results from statistically designed experiments enabled establishment of mathematical models and equations that were used for detailed characterization of influence of identified CPP upon MDDC particle size and particle size distribution and their subsequent optimization. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, High-Throughput HPLC-MS/MS Method for Quantification of Ibuprofen Enantiomers in Human Plasma: Focus on Investigation of Metabolite Interference(Oxford University Press (OUP), 2016-11-30); ; ;