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Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery
(Beilstein Institut, 2026-01-13)
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Zimmer, Andreas
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Geiss, Otmar
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Toxicity of weight loss supplements in human liver HepG2 cells
(2022)
Zhivikj, Zoran
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Petreska Ivanovska, Tanja
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Shalabalija, Dushko
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Shutevska, Kristina
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Formulation and characterization of snail slime-chitosan microparticles with herbal extracts intended for treatment of chronic wounds
(2022)
Nestorovska, Martina
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Cenova, Anastazija
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Shalabalija, Dushko
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Mihailova, Ljubica
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Evaluation of antioxidant properties of herbal mixture and CBD oil for the treatment of chronic wound
(Macedonian pharmaceutical association, 2022)
Cenova, Anastazija
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Nestorovska, Martina
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Mihailova, Ljubica
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Shalabalija, Dushko
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Spray-dried snail mucus as raw material with potential for chronic wound treatment
(Macedonian pharmaceutical association, 2022)
Tasevska, Teodora
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Shalabalija, Dushko
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Mihailova, Ljubica
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Polenakovic, Radmil
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Insight into the efficacy of lipid nano-systems for brain delivery – uptake and internalization pathways in different cell culture lines
(Macedonian pharmaceutical association, 2022)
Mihailova,Ljubica
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Shalabalija, Dushko
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Lipid nano-carriers with herbal extracts for targeted brain delivery and treatment of CNS disorders
(Macedonian pharmaceutical association, 2022)
Shalabalija, Dushko
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Mihailova, Ljubica
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Lipid nano-carriers loaded with a extract for epilepsy treatment characterization and efficacy studies
(Elsevier BV, 2022-09)
Mihailova, Ljubica
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Tchekalarova, Jana
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Shalabalija, Dushko
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Geskovski, Nikola
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Stoilkovska Gjorgievska, Veronika
Taking into consideration the latest reported beneficial anticolvusant effects of cannabidiol (CBD) and cannabiodiolic acid (CBDA) for clinical applications and the advantages of lipid nano-systems as carriers for targeted brain delivery, the aim of this study was set in direction of in vitro physico-chemical and biopharmaceutical characterization and in vivo evaluation of nanoliposomes and nanostructured lipid carriers loaded with Cannabis sativa extract intended for safe and efficient transport via blood-brain barrier and treatment of epilepsy. These nanoliposomes and nanostructured lipid formulations were characterized with z-average diameter <200 nm, following unimodal particle size distribution, negative values for Z-potential, high drug encapsulation efficiency and prolonged release during 24h (38.84-60.91 %). Prepared formulations showed statistically significant higher antioxidant capacity compared to the extract. The results from in vivo studies of the anticonvulsant activity demonstrated that all formulations significantly elevated the latencies for myoclonic, clonic and tonic seizures and, therefore, could be used in preventing different types of seizures. A distinction in the potential of the nano-systems was noted, which was probably anticipated by the type and the characteristics of the prepared formulations.
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Cytotoxicity and cellular uptake of Cannabis sativa extract loaded nanostructured lipid carriers on hCMEC/D3 cells
(2021-02-08)
Ljubica Mihailova
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Shalabalija, Dushko
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Zimmer, Andreas
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Stefkov, Gjose
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Antibiotic consumption and management at Kocani General Hospital – Annual report
(Macedonian Pharmaceutical Association, 2019)
Ilieva, Nada
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Nikolova, Milena
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Pankov, Donka
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Simonoska Crcarevska, Maja
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<jats:p>The aim of the study was to get detailed insight into the antibiotic consumption trends in the three year period (2016-2018) in Kocani Hospital, to identify the most often prescribed antibiotics and to determine whether the treatment of given diagnosis was in accordance with the official guidelines. The survey covered all pediatric and infant patients admitted to the pediatric ward. Patients’ data included gender, age, diagnosis, antibiotic used and doses. The majority of admitted patients were in the age group of 0-1 (27.48%, 25.94% and 30.77% for 2016, 2017 and 2018, accordingly) followed by age group of 1-2 years (20.86%, 22,0% and 23.83% for 2016, 2017 and 2018, consequently) and 2-3 years (16.06%, 16.1% and 14.63% for 2016, 2017 and 2018, consequently) .The most frequent diagnosis was acute tonsillitis which was determined in ~21% of patients, pneumonia without complications in ~18% and acute bronchitis in ~16% of patients in the period 2016-2018. Results from conducted survey identified high prescription rate and use of antibiotics predominantly ceftriaxone (82.58%, 81.05% and 50.85% in 2016, 2017 and 2018, respectively) contrary to official recommendations and evidences based on clinical data for treatment of the diagnoses in question. So, it is foreseeable to conclude that there is urgent need for restrictive and educational measures i.e. to strength the surveillance and monitoring of antibiotic prescription and usage and hence to promote awareness for rational use of antibiotics on all health-care levels. Key words: antibiotic prescription, antibiotic consumption, pediatric wards, annual report</jats:p>

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