Faculty of Pharmacy

Permanent URI for this communityhttps://repository.ukim.mk/handle/20.500.12188/17

Browse

Search Results

Now showing 1 - 10 of 11

Some of the metrics are blocked by your
consent settings
Comparative Modeling Approaches in the Development and Evaluation of Silica Nanoparticles as 5-Fluorouracil Carriers using PLS, DoE and GBR
(Springer Science and Business Media LLC, 2025-11-24)
Djurdjic, Beti
;
;
Dimkovska, Teodora
;
;
Some of the metrics are blocked by your
consent settings
Comparative Modeling Approaches in the Development and Evaluation of Silica Nanoparticles as 5-Fluorouracil Carriers using PLS, DoE and GBR
(Springer Science and Business Media LLC, 2025-11-24)
Djurdjic, Beti
;
;
Dimkovska, Teodora
;
;
Some of the metrics are blocked by your
consent settings
Design of ophthalmic micelles loaded with diclofenac sodium: effect of chitosan and temperature on the block-copolymer micellization behaviour
(Springer Science and Business Media LLC, 2022-06-01)
Koummich, Sarra Aicha
;
Zoukh, Ikram Mustapha
;
Gorachinov, Filip
;
Geskovski, Nikola
;
TY - JOUR AU - Koummich, Sarra Aicha AU - Zoukh, Ikram Mustapha AU - Gorachinov, Filip AU - Geskovski, Nikola AU - Makreski, Petre AU - Dodov, Marija Glavas AU - Goracinova, Katerina PY - 2022 DA - 2022/06/01 TI - Design of ophthalmic micelles loaded with diclofenac sodium: effect of chitosan and temperature on the block-copolymer micellization behaviour JO - Drug Delivery and Translational Research SP - 1488 EP - 1507 VL - 12 IS - 6 AB - Diclofenac sodium 0.1% is a commonly used NSAID with well-documented clinical efficacy in reducing postoperative inflammation; however, its corneal tolerability and ophthalmic tissue bioavailability require further improvement. Advanced micellar delivery systems composed of block-copolymers and chitosan showing fine balance between the mucoadhesion and mucus permeation, capable to slip through the mucus barrier and adhere to the epithelial ocular surface, may be used to tackle both challenges. The aggregation behaviour of the block-copolymers in the presence of different additives will dramatically influence the quality attributes like particle size, particle size distribution, drug-polymer interaction, zeta potential, drug incorporation, important for the delicate balance among mucoadhesion and permeation, as well as safety and efficacy of the ophthalmic micelles. Therefore, quality by design approach and D-optimal experimental design model were used to create a pool of useful data for the influence of chitosan and the formulation factors on the block copolymer’s aggregation behaviour during the development and optimization of Diclofenac loaded Chitosan/Lutrol F127 or F68 micelles. Particle size, polydispersity index, dissolution rate, FTIR and DSC studies, NMR spectroscopy, cytotoxicity, mucoadhesivity, mucus permeation studies, and bioadhesivity were assessed as critical quality attributes. FTIR and DSC studies pointed to the chaotropic effect of chitosan during the micelle aggregation. Mainly, Pluronic F68 micellization behaviour was more dramatically affected by the presence of chitosan, and self-aggregation into larger micelles with high polydispersity index was favoured at higher chitosan concentration. The optimized formulation with highest potential for ophthalmic delivery of diclofenac sodium, good cytotoxicity profile, delicate balance of the mucoadhesivity, and mucus permeation was in the design space of Chitosan/Lutrol F127 micelles. SN - 2190-3948 UR - https://doi.org/10.1007/s13346-021-01030-4 DO - 10.1007/s13346-021-01030-4 ID - Koummich2022 ER -
Some of the metrics are blocked by your
consent settings
Nanotechnology in medicine – our experiences
(Macedonian pharmaceutical association, 2022)
;
Mraiche, Fatima
;
Yalcin, Huseyin C.
;
Gorachinov, Filip
;
Moustafa, Diala A.
Some of the metrics are blocked by your
consent settings
Tablets of soy protein-alginate microparticles with Lactobacillus casei 01: Physicochemical and biopharmaceutical properties
(National Library of Serbia, 2019)
Hadzieva, Jasmina
;
Glavas-Dodov, Marija
;
Simonoska-Crcarevska, Maja
;
Koprivica, Blagorodna
;
Dimchevska, Simona
<jats:p>The aim of the study was to develop direct-compress-tablets of microencapsulated probiotic Lactobacillus casei 01 in soy protein-alginate microparticles and excipients able to provide probiotic delivery near the colon. Considering their physicochemical properties, all series of tablets prepared met the requirements of the Ph Eur 9.0. The compaction of the probiotic loaded microparticles caused viability decrease up to 1.5 log cycles. The tablets containing Methocel K100M showed higher potential for preserving probiotic viability in simulated gastrointestinal fluids within 4 h and retarding its release in the intestinal stage, maintaining the required minimum of viable probiotic cells above 107 CFU per gram of tablet. In addition, acceptable storage stability (viability of probiotic above 106 CFU/g) at 25?C/60% relative humidity for 42 days was observed. In conclusion, novel tablet dosage forms of microencapsulated L. casei 01 were prepared with high potential for preserving probiotic viability in simulated gastrointestinal fluids and retarding its release in the lower intestine. Further research is needed to optimize the formulation and process parameters in order to obtain tablets with probiotic viability over long storage periods.</jats:p>
Some of the metrics are blocked by your
consent settings
Lactobacillus casei Encapsulated in Soy Protein Isolate and Alginate Microparticles Prepared by Spray Drying
(Faculty of Food Technology and Biotechnology - University of Zagreb, 2017-06)
Hadzieva, Jasmina
;
;
Crcarevska, Maja Simonoska
;
Dodov, Marija Glavaš
;
Dimchevska, Simona
This article presents a novel formulation for preparation of Lactobacillus casei 01 encapsulated in soy protein isolate and alginate microparticles using spray drying method. A response surface methodology was used to optimise the formulation and the central composite face-centered design was applied to study the effects of critical material attributes and process parameters on viability of the probiotic after microencapsulation and in simulated gastrointestinal conditions. Spherical microparticles were produced in high yield (64%), narrow size distribution (d50=9.7 µm, span=0.47) and favourable mucoadhesive properties, with viability of the probiotic of 11.67, 10.05, 9.47 and 9.20 log CFU/g after microencapsulation, 3 h in simulated gastric and intestinal conditions and four-month cold storage, respectively. Fourier-transform infrared spectroscopy confirmed the probiotic stability after microencapsulation, while differential scanning calorimetry and thermogravimetry pointed to high thermal stability of the soy protein isolate-alginate microparticles with encapsulated probiotic. These favourable properties of the probiotic microparticles make them suitable for incorporation into functional food or pharmaceutical products.
Some of the metrics are blocked by your
consent settings
Drug Targeting in IBD Treatment – Existing and New Approaches
(InTech, 2012-01-27)
Goracinova, Katerina
;
Glavas-Dodov, Marija
;
Simonoska-Crcarevska, Maja
;
Geskovski, Nikola
Some of the metrics are blocked by your
consent settings
Chitosan coated Ca-alginate microparticles loaded with budesonide for delivery to the inflamed colonic mucosa
(Elsevier BV, 2008-03)
Simonoska Crcarevska, Maja
;
Glavas Dodov, Marija
;
Goracinova, Katerina
Using a novel one-step spray-drying process uncoated and Eudragit S 100 coated chitosan-Ca-alginate microparticles efficiently loaded with budesonide (BDS), with bioadhesive and controlled release properties in GIT, were prepared. Microparticles were spherical with mean particle size of 4.05-5.36 microm, narrow unimodal distribution and positive surface charge. A greater extent of calcium chloride limited the swelling ratio of beads, while swelling behaviour of coated beads was mainly determined by properties of enteric coating. Comparing the release profiles of formulations, under different pH conditions, influence of polymer properties and concentration of cross-linker on the rate and extent of drug release was evident. Coating has successfully sustained release of BDS in buffers at pH 2.0 and 6.8, while providing potential for efficient release of BDS at pH 7.4. Release data kinetics indicated influence of erosion and biodegradation of polymer matrix on drug release from microparticles. Prepared formulations were stable for 12 months period at controlled ambient conditions. In conclusion coated microparticles prepared by one-step spray-drying procedure could be suitable candidates for oral delivery of BDS with controlled release properties for local treatment of inflammatory bowel diseases.
Some of the metrics are blocked by your
consent settings
Comparative biodistribution studies of technetium-99 m radiolabeled amphiphilic nanoparticles using three different reducing agents during the labeling procedure
(Wiley, 2013-12)
Geskovski, Nikola
;
;
Simonoska Crcarevska, Maja
;
Calis, Sema
;
Dimchevska, Simona
Considering the confusing biodistribution data through the literature and few reported alerts as well as our preliminary biodistribution results, we decided to evaluate the interaction and interference of the commonly present (99m) Tc (technetium-99m)-stannic oxide colloid during the direct stannous chloride (99m) Tc-labeling procedure and to assess its influence on the biodistribution pattern of amphiphilic poly(lactic-co-glycolic acid) nanoparticles. In order to confirm our thesis, beside stannous chloride, we employed two different reducing agents that don't form colloidal particles. The use of sodium borohydride was previously reported in the literature, whereas sodium dithionite was adapted for the first time in the (99m) Tc direct labeling procedure for nanoparticles. The results in our paper clearly differentiate among samples with and without colloidal impurities originating from the labeling procedure with a logical follow up of the radiochemical, physicochemical evaluation, and biodistribution studies clarifying previously reported data on stannic oxide colloidal interference. (99m) Tc-nanoparticle complex labeled with sodium dithionite as reducing agent illustrated appropriate labeling efficacy, stability, and potential for further use in biodistribution studies thus providing solution for the problem of low-complex stability when sodium borohydride is used and colloidal stannic oxide interference for stannous chloride procedure.
Some of the metrics are blocked by your
consent settings
The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors
(Beilstein Institut, 2021-04-29)
Geskovski, Nikola
;
Matevska-Geshkovska, Nadica
;
Dimchevska Sazdovska, Simona
;
Glavas Dodov, Marija
;
Nanomedicine has emerged as a novel cancer treatment and diagnostic modality, whose design constantly evolves towards increasing the safety and efficacy of the chemotherapeutic and diagnostic protocols. Molecular diagnostics, which create a great amount of data related to the unique molecular signatures of each tumor subtype, have emerged as an important tool for detailed profiling of tumors. They provide an opportunity to develop targeting agents for early detection and diagnosis, and to select the most effective combinatorial treatment options. Alongside, the design of the nanoscale carriers needs to cope with novel trends of molecular screening. Also, multiple targeting ligands needed for robust and specific interactions with the targeted cell populations have to be introduced, which should result in substantial improvements in safety and efficacy of the cancer treatment. This article will focus on novel design strategies for nanoscale drug delivery systems, based on the unique molecular signatures of myeloid leukemia and EGFR/CD44-positive solid tumors, and the impact of novel discoveries in molecular tumor profiles on future chemotherapeutic protocols.

Faculty of Pharmacy

Browse

Filters

Settings

Sort By

Results per page

Search Results