Faculty of Pharmacy

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Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery
(Beilstein Institut, 2026-01-13)
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Zimmer, Andreas
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Geiss, Otmar
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Bacterial Nanocellulose Wound Dressings with Gentamicin-Loaded Chitosan Nanoparticles for Surgical Site Infection Management
(MDPI AG, 2026-02-19)
Livrinska Trpeska, Lina
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Petrushevska, Marija
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Djurdjic, Beti
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Comparative Modeling Approaches in the Development and Evaluation of Silica Nanoparticles as 5-Fluorouracil Carriers using PLS, DoE and GBR
(Springer Science and Business Media LLC, 2025-11-24)
Djurdjic, Beti
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Dimkovska, Teodora
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Comparative Modeling Approaches in the Development and Evaluation of Silica Nanoparticles as 5-Fluorouracil Carriers using PLS, DoE and GBR
(Springer Science and Business Media LLC, 2025-11-24)
Djurdjic, Beti
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Dimkovska, Teodora
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Novel development of lipid-based formulations: Improved wettability and homogeneous API solid dispersion visualised via near-infrared hyperspectral imaging
(Elsevier BV, 2025-11)
Atanaskova, Elizabeta
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Poms, Johannes
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Wolfgang, Matthias
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Alva, Carolina
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Mussner, Nadia
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Toxicity of weight loss supplements in human liver HepG2 cells
(2022)
Zhivikj, Zoran
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Petreska Ivanovska, Tanja
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Shalabalija, Dushko
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Shutevska, Kristina
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PLS based quantitative determination of insulin aspart in solution using Raman spectroscopy
(Centre for Evaluation in Education and Science (CEON/CEES), 2024)
Godzo, Hrisanta
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<jats:p>The complex structure of medicines containing polypeptide active substances requires the implementation of challenging analytical approaches, based on physicochemical methods, and, where necessary, biological assays for quality control, as well as for the detection of substandard and falsified products. Vibrational spectroscopic techniques, including Raman spectroscopy, are fast, powerful, and non-destructive techniques which, when combined with multivariate chemometric modelling, can provide specific identification, quantitative determination, and insight into the secondary structure of proteins and peptides. The aim of this study was to investigate the possibility of using Raman spectroscopy as a screening method for quantification of pharmaceutical products containing active substances with polypeptide structures. For that purpose, a model based on partial least square (PLS) analysis for quantitative determination of insulin aspart in solution was developed using Raman spectroscopy. The proposed model enables the establishment of a rapid approach for screening of the quality of formulations containing active substances with polypeptide structure, providing the selection of suspected samples that should be further analysed using routine techniques, which are time-consuming and costly.</jats:p>
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Design of ophthalmic micelles loaded with diclofenac sodium: effect of chitosan and temperature on the block-copolymer micellization behaviour
(Springer Science and Business Media LLC, 2022-06-01)
Koummich, Sarra Aicha
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Zoukh, Ikram Mustapha
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Gorachinov, Filip
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Geskovski, Nikola
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TY - JOUR AU - Koummich, Sarra Aicha AU - Zoukh, Ikram Mustapha AU - Gorachinov, Filip AU - Geskovski, Nikola AU - Makreski, Petre AU - Dodov, Marija Glavas AU - Goracinova, Katerina PY - 2022 DA - 2022/06/01 TI - Design of ophthalmic micelles loaded with diclofenac sodium: effect of chitosan and temperature on the block-copolymer micellization behaviour JO - Drug Delivery and Translational Research SP - 1488 EP - 1507 VL - 12 IS - 6 AB - Diclofenac sodium 0.1% is a commonly used NSAID with well-documented clinical efficacy in reducing postoperative inflammation; however, its corneal tolerability and ophthalmic tissue bioavailability require further improvement. Advanced micellar delivery systems composed of block-copolymers and chitosan showing fine balance between the mucoadhesion and mucus permeation, capable to slip through the mucus barrier and adhere to the epithelial ocular surface, may be used to tackle both challenges. The aggregation behaviour of the block-copolymers in the presence of different additives will dramatically influence the quality attributes like particle size, particle size distribution, drug-polymer interaction, zeta potential, drug incorporation, important for the delicate balance among mucoadhesion and permeation, as well as safety and efficacy of the ophthalmic micelles. Therefore, quality by design approach and D-optimal experimental design model were used to create a pool of useful data for the influence of chitosan and the formulation factors on the block copolymer’s aggregation behaviour during the development and optimization of Diclofenac loaded Chitosan/Lutrol F127 or F68 micelles. Particle size, polydispersity index, dissolution rate, FTIR and DSC studies, NMR spectroscopy, cytotoxicity, mucoadhesivity, mucus permeation studies, and bioadhesivity were assessed as critical quality attributes. FTIR and DSC studies pointed to the chaotropic effect of chitosan during the micelle aggregation. Mainly, Pluronic F68 micellization behaviour was more dramatically affected by the presence of chitosan, and self-aggregation into larger micelles with high polydispersity index was favoured at higher chitosan concentration. The optimized formulation with highest potential for ophthalmic delivery of diclofenac sodium, good cytotoxicity profile, delicate balance of the mucoadhesivity, and mucus permeation was in the design space of Chitosan/Lutrol F127 micelles. SN - 2190-3948 UR - https://doi.org/10.1007/s13346-021-01030-4 DO - 10.1007/s13346-021-01030-4 ID - Koummich2022 ER -
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Analytical Techniques for Phytocannabinoid Profiling of Cannabis and Cannabis-Based Products-A Comprehensive Review
(MDPI AG, 2022-02-01)
Stefkov, Gjoshe
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Cvetkovikj Karanfilova, Ivana
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Stoilkovska Gjorgievska, Veronika
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Trajkovska, Ana
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Geskovski, Nikola
Cannabis is gaining increasing attention due to the high pharmacological potential and updated legislation authorizing multiple uses. The development of time- and cost-efficient analytical methods is of crucial importance for phytocannabinoid profiling. This review aims to capture the versatility of analytical methods for phytocannabinoid profiling of cannabis and cannabis-based products in the past four decades (1980-2021). The thorough overview of more than 220 scientific papers reporting different analytical techniques for phytocannabinoid profiling points out their respective advantages and drawbacks in terms of their complexity, duration, selectivity, sensitivity and robustness for their specific application, along with the most widely used sample preparation strategies. In particular, chromatographic and spectroscopic methods, are presented and discussed. Acquired knowledge of phytocannabinoid profile became extremely relevant and further enhanced chemotaxonomic classification, cultivation set-ups examination, association of medical and adverse health effects with potency and/or interplay of certain phytocannabinoids and other active constituents, quality control (QC), and stability studies, as well as development and harmonization of global quality standards. Further improvement in phytocannabinoid profiling should be focused on untargeted analysis using orthogonal analytical methods, which, joined with cheminformatics approaches for compound identification and MSLs, would lead to the identification of a multitude of new phytocannabinoids.
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Community pharmacy practice in Montenegro in the period January-April 2020
(Macedonian pharmaceutical association, 2022)
Djurdjic, Beti
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Maric, Savo
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