Faculty of Pharmacy
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Item type:Publication, Micro-Raman Spectroscopy for Detection of Label-Free and Oil Red O Labeled PEGylated Nanoliposomes in hCmec/D3 Cell Internalization Studies(Croatian Chemical Society, 2022-12) ;Gorachinov, Filip; ;Shalabalija, Dushko ;Mihailova Ljubica - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparative Studies of the Uptake and Internalization Pathways of Different Lipid Nano-Systems Intended for Brain Delivery(MDPI AG, 2023-08-03) ;Mihailova Ljubica ;Shalabalija Dushko ;Zimmer, Andreas; Lipid nano-systems were prepared and characterized in a series of well-established in vitro tests that could assess their interactions with the hCMEC/D3 and SH-SY5Y cell lines as a model for the blood-brain barrier and neuronal function, accordingly. The prepared formulations of nanoliposomes and nanostructured lipid carriers were characterized by z-average diameters of ~120 nm and ~105 nm, respectively, following a unimodal particle size distribution (PDI < 0.3) and negative Z-potential (-24.30 mV to -31.20 mV). Stability studies implied that the nano-systems were stable in a physiologically relevant medium as well as human plasma, except nanoliposomes containing poloxamer on their surface, where there was an increase in particle size of ~26%. The presence of stealth polymer tends to decrease the amount of adsorbed proteins onto a particle's surface, according to protein adsorption studies. Both formulations of nanoliposomes were characterized by a low cytotoxicity, while their cell viability was reduced when incubated with the highest concentration (100 μg/mL) of nanostructured lipid formulations, which could have been associated with the consumption of cellular energy, thus resulting in a reduction in metabolic active cells. The uptake of all the nano-systems in the hCMEC/D3 and SH-SY5Y cell lines was successful, most likely following ATP-dependent internalization, as well as transport via passive diffusion. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Nanotechnology - a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer(BEILSTEIN INSTITUT, 2023-02-22) ;Gorachinov, Filip ;Mraiche, Fatima ;Moustafa, Diala Alhaj ;Hishari, OlaIsmail, YomnaGenomic and proteomic mutation analysis is the standard of care for selecting candidates for therapies with tyrosine kinase inhibitors against the human epidermal growth factor receptor (EGFR TKI therapies) and further monitoring cancer treatment efficacy and cancer development. Acquired resistance due to various genetic aberrations is an unavoidable problem during EGFR TKI therapy, leading to the rapid exhaustion of standard molecularly targeted therapeutic options against mutant variants. Attacking multiple molecular targets within one or several signaling pathways by co-delivery of multiple agents is a viable strategy for overcoming and preventing resistance to EGFR TKIs. However, because of the difference in pharmacokinetics among agents, combined therapies may not effectively reach their targets. The obstacles regarding the simultaneous co-delivery of therapeutic agents at the site of action can be overcome using nanomedicine as a platform and nanotools as delivery agents. Precision oncology research to identify targetable biomarkers and optimize tumor homing agents, hand in hand with designing multifunctional and multistage nanocarriers that respond to the inherent heterogeneity of the tumors, may resolve the challenges of inadequate tumor localization, improve intracellular internalization, and bring advantages over conventional nanocarriers. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Formulation and characterization of snail slime-chitosan microparticles with herbal extracts intended for treatment of chronic wounds(2022) ;Nestorovska, Martina ;Cenova, Anastazija; ;Shalabalija, DushkoMihailova, Ljubica - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of antioxidant properties of herbal mixture and CBD oil for the treatment of chronic wound(Macedonian pharmaceutical association, 2022) ;Cenova, Anastazija ;Nestorovska, Martina; ;Mihailova, LjubicaShalabalija, Dushko - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pharmacy students' experience during the Covid-19 pandemic and its impact on their health, academic endeavors and overall perceptions-a study(Macedonian pharmaceutical association, 2022) ;Naumovski, Metodi ;Dodov, Teodora ;Mihailova, Ljubica; Slaveska Raicki, Renata - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Community pharmacy practice in Montenegro in the period January-April 2020(Macedonian pharmaceutical association, 2022) ;Djurdjic, Beti ;Maric, Savo; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Role and activities of pharmacists in RN Macedonia at the beginning of COVID-19 pandemic: March-April 2020(Macedonian pharmaceutical association, 2022); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Community pharmacists in RN Macedonia at the frontline of COVID-19 pandemic beginning: March-April 2020(Macedonian pharmaceutical association, 2022); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Building a draft national strategy for implementation of pharmaceutical care in patients with chronic diseases in Republic of North Macedonia(Macedonian pharmaceutical association, 2022) ;Pankov, Donka; ;
