Faculty of Dentistry

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Subject: search.filters.subject.atorvastatin, medication-related ostenecrosis of the jaw

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    ATORVASTATIN PREVENTS MEDICATION-RELATED OSTEONECROSIS OF THE JAW IN RATS
    (Elsevier BV, 2024-01)
    Koneski, F.
    ;
    Monevska, D. Popovik
    ;
    Popovski, V.
    ;
    Kirkov, A.
    ;
    Dvojakovska, S. Bozovic
    Background: Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication of antiresorptive drugs, that is still a subject of clinical and experimental research. Recent studies show that statins might have a potential positive effect on bone metabolism via stimu- lation of osteoblastic activity. Aim: The aim of this study is to assess the effects of atorvastatin on the prevention of MRONJ. Methods: Twenty-five white laboratory Wistar rats were divided equally in five groups. Positive control group received only saline i.p. while all other groups received 0.06 mg/kg zoledronic acid i.p., once weekly for seven weeks, including the negative control group. In addition, examined groups 1, 2 and 3 received a single atorvastatin injection on the extraction site immediately after the extraction, once weekly intraperitoneal atorvastatin in- jection for seven weeks, and local injection of atorva- statin two weeks after the tooth extraction, respectively. Tooth extraction was performed in all groups on day 21. Clinical scores of wound healing and three-dimensional cone-beam computed tomography (CBCT) were per- formed to evaluate the occurrence of MRONJ. Mann- Whitney U test was used for statistical analysis and P value of <0.05 was considered as significant. Results: Negative control group showed significantly impaired wound healing, with exposed necrotic bone, confirmed with osteolytic lesions on CBCT. All groups treated with atorvastatin showed statistically sig- nificant improved wound healing, less osteonecrosis and better scores on CBCT evaluation, when com- pared to negative control group, but similar to posi- tive control group. Conclusion: Atorvastatin may be an option for preven- tion and treatment of MRONJ.