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http://hdl.handle.net/20.500.12188/9604| Title: | The calcimimetic R-568 retards uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE-/-) mice | Authors: | Ivanovski, Ognen Nikolov, Igor G Joki, Nobuhiko Caudrillier, Axelle Phan, Olivier Mentaverri, Romuald Maizel, Julien Hamada, Yasuhiro Nguyen-Khoa, Thao Fukagawa, Masafumi Kamel, Said Lacour, Bernard Drüeke, Tilman B Massy, Ziad A |
Issue Date: | Jul-2009 | Publisher: | Elsevier BV | Journal: | Atherosclerosis | Abstract: | Secondary hyperparathyroidism of chronic kidney disease promotes vascular calcification. Calcimimetics reduce serum parathyroid hormone, calcium (Ca), and phosphorus by calcium-sensing receptor (CaR) activation. Here we examined possible effects of the calcimimetic R-568 (R-568) on the progression of aortic calcification and atherosclerosis in apoE(-/-) mice with chronic renal failure (CRF) and the potential implication of aortic smooth muscle cell CaR. | URI: | http://hdl.handle.net/20.500.12188/9604 | DOI: | 10.1016/j.atherosclerosis.2008.10.043 |
| Appears in Collections: | Faculty of Medicine: Journal Articles |
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