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http://hdl.handle.net/20.500.12188/9597| Title: | Farnesyltransferase inhibitor R115777 protects against vascular disease in uremic mice | Authors: | Nikolov, Igor G Joki, Nobuhiko Galmiche, Antoine Nguyen-Khoa, Thao Guerrera, Ida Chiara Guillonneau, François Ivanovski, Ognen Phan, Olivier Maizel, Julien Marçon, Frédéric Benchitrit, Joyce Lucas, Anthony Edelman, Aleksander Lacour, Bernard Drüeke, Tilman B Massy, Ziad A |
Issue Date: | Jul-2013 | Publisher: | Elsevier BV | Journal: | Atherosclerosis | Abstract: | Atherosclerosis and vascular calcification are major contributors to cardiovascular morbidity and mortality among chronic kidney disease patients. The mevalonate pathway may play a role in this vascular pathology. Farnesyltransferase inhibitors such as R115777 block one branch of mevalonate pathway. We studied the effects of farnesyltransferase inhibitor R115777 on vascular disease in apolipoprotein E deficient mice with chronic renal failure and on mineral deposition in vitro. | URI: | http://hdl.handle.net/20.500.12188/9597 | DOI: | 10.1016/j.atherosclerosis.2013.02.041 |
| Appears in Collections: | Faculty of Medicine: Journal Articles |
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