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Наслов: Cold exposure down-regulates zebrafish pigmentation
Authors: Kulkeaw, Kasem
Ishitani, Tohru
Kanemaru, Takaaki
Ivanovski, Ognen 
Nakagawa, Midori
Mizuochi, Chiyo
Horio, Yuka
Sugiyama, Daisuke
Issue Date: апр-2011
Publisher: Wiley
Journal: Genes to cells : devoted to molecular & cellular mechanisms
Abstract: Vertebrates use adaptive mechanisms when exposed to physiologic stresses. However, the mechanisms of pigmentation regulation in response to physiologic stresses largely remain unclear. To address this issue, we developed a novel pigmentation model in adult zebrafish using coldwater exposure (cold zebrafish). When zebrafish were maintained at 17 °C, the pigmentation of their pigment stripes was reduced compared with zebrafish at 26.5 °C (normal zebrafish). In cold zebrafish, gene expression levels of tyrosinase and dopachrome tautomerase, which encode enzymes involved in melanogenesis, were down-regulated, suggesting that either down-regulation of melanin synthesis occurred or the number of melanophores decreased. Both regular and electron microscopic observation of zebrafish skin showed that the number of melanophores decreased, whereas aggregation of melanosomes was not changed in cold zebrafish compared with normal zebrafish. Taken together, we here show that cold exposure down-regulated adult zebrafish pigmentation through decreasing the number of melanophores and propose that the cold zebrafish model is a powerful tool for pigmentation research.
URI: http://hdl.handle.net/20.500.12188/9592
DOI: 10.1111/j.1365-2443.2011.01498.x
Appears in Collections:Faculty of Medicine: Journal Articles

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