Физиолошки нарушувања кај аутизмот

Abstract

Autism is a neurological disorder that limits a person ’s ability to function normally. Behavioral abnormalities, social limitations, sensory processing abnormalities, and impaired ability to communicate are the main issues in this multifactorial disorder. The increase in the rate of autism revealed by epidemiological studies implicates the importance of external or environmental factors. The aim of article is to show all data from literature concerning to physiological abnormalities in autistic persons. Autism etiopathology is still poorly defined but likely multifactorial with her liability playing a major role. Autistic children frequently have physiological abnormalities. Sulfoxidation and sulfation abnormalities can compromise liver detoxification, which may contribute to the high body burden of xenobiotics. Copper-zinc imbalance implies metallothionein impairment that could compound the negative impact of sulfur metabolism impairments on detoxification and on intestinal lining integrity. Intestinal hyperpermeability is manifested as dysbiosis, food intolerance, and exorphin (opioid) intoxication. Immune system abnormalities encompass derangement of antibody production, skewing of T cell subsets, aberrant cytokine profiles, and other impairments consistent with chronic inflammation and autoimmunity. This article also discusses the evidence for toxicity and oxidative stress and the possible involvement of glutathione. Finally, coagulation and mineral abnormalities have been reported.