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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/8100
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dc.contributor.authorBabulovska A.en_US
dc.contributor.authorCaparoska D.en_US
dc.contributor.authorVelikj-Stefanovska V.en_US
dc.contributor.authorSimonovska N.en_US
dc.contributor.authorPereska Z.en_US
dc.contributor.authorKostadinoski K.en_US
dc.contributor.authorNaumoski K.en_US
dc.date.accessioned2020-05-13T06:36:30Z-
dc.date.available2020-05-13T06:36:30Z-
dc.date.issued2020-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/8100-
dc.description.abstractThe aim of the study is to identify possible differences in de￾mographic, laboratory and clinical characteristics between pa￾tients with rhabdomyolysis due to intoxication with psychoac￾tive and chemical substances. The study is a cross-sectional study conducted between 1 Janu￾ary and 30 June 2019. All the patients included during this period were treated due to intoxication (outpatient or hospitalized) at the University Clinic of Toxicology in Skopje. The patients with rhab￾domyolysis were divided in two groups according to the nature of the substance used for intoxication: a) psychoactive substances and b) a chemical substance. Rhabdomyolysis was determined with a value of CPK (creatinine phosphate kinase) >250 U/L. Patients with rhabdomyolysis due to intoxication with chemi￾cal substances were significantly older than patients with rhab￾domyolysis due to intoxication with psychoactive substances. There is a significant difference between the two groups of pa￾tients with rhabdomyolysis in terms of CPK, urea, hemoglobin values during the first day with regards to significantly higher values in the group where intoxication occurred with psychoac￾tive substances. Five patients with rhabdomyolysis due to intoxication with psychoactive substances experienced muscle pain (10.9%), and one patient (3.8%) of those with rhabdomyolysis due to intoxi￾cation with chemicals, without any significant association be￾tween muscle pain and type of intoxication (Fisher exact test: p=0.3003). Muscle weakness and pigmented urine were iden￾tified consequently in six patients (13.0%) vs. five (10.9%) of patients with psychoactive intoxication and none with chemical. Rhabdomyolysis caused by psychoactive and chemical sub￾stances is associated with clinical manifestations and biochemi￾cal abnormalities. The values of CPK, myoglobin, AST, ALT, LDH, urea and creatinine were higher in favor of the group of intoxicated patients with rhabdomyolysis with psychoactive substances. The clinical symptoms of rhabdomyolysis are not present in all intoxicated patients, but are more present in the group intoxicated with psychoactive substances. Biochemical findings are crucial in establishing the diagnosis of rhabdomyol￾ysis. Abnormalities of biochemical findings need to be identified in order to initiate appropriate treatment immediately to prevent mortality and morbidity.en_US
dc.language.isoenen_US
dc.relation.ispartofGeorgian Medical Newsen_US
dc.subjectrhabdomyolysisen_US
dc.subjectintoxicationen_US
dc.subjectpsychotropic substancesen_US
dc.subjectchemicals substancesen_US
dc.subjectbiochemical findingsen_US
dc.titleCLINICAL AND BIOCHEMICAL FINDINGS OF RHABDOMYOLYSIS IN ACUTE INTOXICATIONS WITH PSYCHOACTIVE AND CHEMICAL SUBSTANCESen_US
dc.typeArticleen_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
Appears in Collections:Faculty of Medicine: Journal Articles
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