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http://hdl.handle.net/20.500.12188/26438
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Georgievska, Jadranka | en_US |
dc.contributor.author | Tofoski, Gligor | en_US |
dc.contributor.author | Dimitrov, Goran | en_US |
dc.contributor.author | Daneva Markova, Ana | en_US |
dc.contributor.author | Jovanovska, Viktorija | en_US |
dc.contributor.author | Dabeski, Drage | en_US |
dc.contributor.author | Jovchevski, Sashe | en_US |
dc.contributor.author | Dzikova, Elena | en_US |
dc.contributor.author | Atanasova, Aleksandra | en_US |
dc.date.accessioned | 2023-05-10T08:43:03Z | - |
dc.date.available | 2023-05-10T08:43:03Z | - |
dc.date.issued | 2022-08-12 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/26438 | - |
dc.description.abstract | Endometriosis is a multifactorial disease which etiopathogenesis has not been elucidated. One of the theories of etiopathogenesis is the inflammatory theory. Aims of the study: To develop a practical non-invasive test for the diagnosis of endometriosis by examining some inflammatory markers and cytokines; to compare the highly sensitive C-reactive protein (hsCRP), cytokines (interleukin-6-IL-6 and tumor necrotizing factor alpha) and the tumor marker cancer antigen 125 (CA-125) among healthy patients and patients with endometriosis; to determine the sensitivity and specificity of each biomarker separately in the diagnosis of endometriosis and to determine their role in the diagnosis of endometriosis. Materials and methods: In a prospective study conducted at the University Clinic for Gynecology and Obstetrics, Ss. Cyril and Methodius University in Skopje, North Macedonia 138 patients were included of a reproductive age between 18-50 years (83 with diagnosis endometriosis operated laparoscopically or with laparotomy) and a control group of 55 healthy women, in a period between 01.09.2018 to 01.05.2021. Serum levels of IL-6, TNF-α, hs-CRP and tumor marker CA-125 were evaluated in both groups. Results: Serum levels of CA-125, IL-6 and TNF-α and hs-CRP were significantly higher in patients with endometriosis compared to the control group. The surface under the ROC curve (AUC) for IL-6, CA-125, hs-CRP, and TNF-α has shown that as individual markers they all have a discriminatory capacity to diagnose patients with endometriosis. Conclusions: Results obtained in our study showed statistically significantly higher serum concentrations of CA-125, IL-6 and TNF-α and hs-CRP in patients with endometriosis compared to the control group of patients. However, none of these biomarkers showed a high sensitivity for diagnosis of endometriosis. It is necessary to find a panel combination of biomarkers with a high sensitivity of about 100% that will enable early diagnosis of endometriosis. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia | en_US |
dc.relation.ispartof | Archives of Public Health | en_US |
dc.title | The role of some inflammatory markers, cytokins and tumor markers in diagnosis of endometriosis | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3889/aph.2022.6060 | - |
dc.identifier.url | https://www.id-press.eu/aph/article/download/6060/5579 | - |
dc.identifier.url | https://www.id-press.eu/aph/article/download/6060/5579 | - |
dc.identifier.volume | 14 | - |
dc.identifier.issue | 2 | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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File | Опис | Size | Format | |
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georgievska-58-71-1 2022.pdf | 1.4 MB | Adobe PDF | View/Open |
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