Cardiac and lipid markers as predictors for coronary artery disease in prediabetic patients

Abstract

Introduction: Coronary artery disease (COPD) is the leading cause of mortality and morbidity in patients with type 2 diabetes mellitus (DMt2). One of the diagnostic methods for assessing CAD is laboratory blood tests that include: lipid status and cardiac markers. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a cardiac biomarker whose predictive power for cardiovascular events in patients with DMT2 and prediabetes is the target of this case study. Apolipoproteins A and B are lipid biomarkers that correlate with atherosclerosis and are factors for cardiovascular events. Materials and Methods: This is a case study of a 38-year-old patient followed over a 12-month period. The respondent was called for laboratory tests every 3 months in the first year. The change in the levels of cardiac and lipid markers NT-proBNP and apolipoprotein A and B was monitored. Results: The case study examines the correlation between the increased values of NT-proBNP and Apolipoprotein A and B with the predictability for CAD at the beginning and during follow-up in a patient with prediabetes. In patients with prediabetes, the increased value of cardiac and lipid biomarkers is expected to be a predictor of coronary events. Antilipemic and antiaggregation therapy is also expected to have a protective effect on cardiovascular events. Conclusion: Determining the association of elevated cardiac and lipid marker values in the occurrence of CAB in patients with prediabetes and timely use of antiliepemic and antiaggregation therapy may prevent unwanted cardiovascular events in diabetic patients.