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http://hdl.handle.net/20.500.12188/18261
Title: | Gene polymorphisms of 22 cytokines in Macedonian children with atopic dermatitis | Authors: | Stavrikj, Katarina Peova, Sonja Trajkov, Dejan Spiroski, Mirko |
Issue Date: | Mar-2012 | Source: | Stavric K, Peova S, Trajkov D, Spiroski M. Gene polymorphisms of 22 cytokines in Macedonian children with atopic dermatitis. Iran J Allergy Asthma Immunol. 2012 Mar;11(1):37-50. PMID: 22427475. | Journal: | Iranian journal of allergy, asthma, and immunology | Abstract: | Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with abnormal cytokine production, and activation of T-helper 2 cells. The aim if this study was to determine whether cytokine gene polymorphisms might influence the development of AD. Single nucleotide polymorphisms in the genes for I-L1alpha, IL-1beta, IL-1R, IL-2, IL-4, IL-6, IL-10, IL-12, TGF beta, TNF and IFNgamma were investigated by PCR and sequence specific primers in Macedonian patients with AD (67 children, age of 6 months to 5 years) and 301 normal unrelated individuals. Susceptible cytokine polymorphisms for AD for eleven genotypes (IL-4 -33/T:T IL-4 -1098/G:G, TGFbeta cdn25C:G, IL-4 -1098/T:T, IL-1alpha -889/C:T, IL-2 +166/T:T, IL-1beta -511/C:T, IL-12 -1188/C:T, IL-10 -1082/A:G, IL-1beta +3962/C:T, IFNgamma +874/A:T), five diplotypes, six haplotypes, and for alleles were found. Protective cytokine polymorphisms for AD for seven cytokine genotypes (IL-4 -1098/G:T, TGFbeta cdn25/G:G, IL-4 -33/C:C, IL-1alpha -889/C:C, IFNgamma +874/A:A, IL-10 -1082/A:A, IL-1beta -511/C:C), one cytokine diplotypes, two cytokine haplotypes, and four cytokine alleles were also found. We concluded that several cytokine polymorphisms are protective, or susceptible associated with AD in population of Macedonians. | URI: | http://hdl.handle.net/20.500.12188/18261 | ISSN: | 1735-1502 |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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