Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/9955
DC Field | Value | Language |
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dc.contributor.author | Johnson, Nichola | en_US |
dc.contributor.author | Maguire, Sarah | en_US |
dc.contributor.author | Morra, Anna | en_US |
dc.contributor.author | Kapoor, Pooja Middha | en_US |
dc.contributor.author | Tomczyk, Katarzyna | en_US |
dc.contributor.author | Jones, Michael E. | en_US |
dc.contributor.author | Schoemaker, Minouk J. | en_US |
dc.contributor.author | Gilham, Clare | en_US |
dc.contributor.author | Bolla, Manjeet K. | en_US |
dc.contributor.author | Wang, Qin | en_US |
dc.contributor.author | Dennis, Joe | en_US |
dc.contributor.author | Ahearn, Thomas U. | en_US |
dc.contributor.author | Andrulis, Irene L. | en_US |
dc.contributor.author | Anton-Culver, Hoda | en_US |
dc.contributor.author | Antonenkova, Natalia N. | en_US |
dc.contributor.author | Arndt, Volker | en_US |
dc.contributor.author | Aronson, Kristan J. | en_US |
dc.contributor.author | Augustinsson, Annelie | en_US |
dc.contributor.author | Baynes, Caroline | en_US |
dc.contributor.author | Freeman, Laura E. Beane | en_US |
dc.contributor.author | Beckmann, Matthias W. | en_US |
dc.contributor.author | Benitez, Javier | en_US |
dc.contributor.author | Bermisheva, Marina | en_US |
dc.contributor.author | Blomqvist, Carl | en_US |
dc.contributor.author | Boeckx, Bram | en_US |
dc.contributor.author | Bogdanova, Natalia V. | en_US |
dc.contributor.author | Bojesen, Stig E. | en_US |
dc.contributor.author | Brauch, Hiltrud | en_US |
dc.contributor.author | Brenner, Hermann | en_US |
dc.contributor.author | Burwinkel, Barbara | en_US |
dc.contributor.author | Campa, Daniele | en_US |
dc.contributor.author | Canzian, Federico | en_US |
dc.contributor.author | Castelao, Jose E. | en_US |
dc.contributor.author | Chanock, Stephen J. | en_US |
dc.contributor.author | Chenevix-Trench, Georgia | en_US |
dc.contributor.author | Clarke, Christine L. | en_US |
dc.contributor.author | Conroy, Don M. | en_US |
dc.contributor.author | Couch, Fergus J. | en_US |
dc.contributor.author | Cox, Angela | en_US |
dc.contributor.author | Cross, Simon S. | en_US |
dc.contributor.author | Czene, Kamila | en_US |
dc.contributor.author | Dörk, Thilo | en_US |
dc.contributor.author | Eliassen, A. Heather | en_US |
dc.contributor.author | Engel, Christoph | en_US |
dc.contributor.author | Evans, D. Gareth | en_US |
dc.contributor.author | Fasching, Peter A. | en_US |
dc.contributor.author | Figueroa, Jonine | en_US |
dc.contributor.author | Floris, Giuseppe | en_US |
dc.contributor.author | Flyger, Henrik | en_US |
dc.contributor.author | Gago-Dominguez, Manuela | en_US |
dc.contributor.author | Gapstur, Susan M. | en_US |
dc.contributor.author | García-Closas, Montserrat | en_US |
dc.contributor.author | Gaudet, Mia M. | en_US |
dc.contributor.author | Giles, Graham G. | en_US |
dc.contributor.author | Goldberg, Mark S. | en_US |
dc.contributor.author | González-Neira, Anna | en_US |
dc.contributor.author | Guénel, Pascal | en_US |
dc.contributor.author | Hahnen, Eric | en_US |
dc.contributor.author | Haiman, Christopher A. | en_US |
dc.contributor.author | Håkansson, Niclas | en_US |
dc.contributor.author | Hall, Per | en_US |
dc.contributor.author | Hamann, Ute | en_US |
dc.contributor.author | Harrington, Patricia A. | en_US |
dc.contributor.author | Hart, Steven N. | en_US |
dc.contributor.author | Hooning, Maartje J. | en_US |
dc.contributor.author | Hopper, John L. | en_US |
dc.contributor.author | Howell, Anthony | en_US |
dc.contributor.author | Hunter, David J. | en_US |
dc.contributor.author | Jager, Agnes | en_US |
dc.contributor.author | Jakubowska, Anna | en_US |
dc.contributor.author | John, Esther M. | en_US |
dc.contributor.author | Kaaks, Rudolf | en_US |
dc.contributor.author | Keeman, Renske | en_US |
dc.contributor.author | Khusnutdinova, Elza | en_US |
dc.contributor.author | Kitahara, Cari M. | en_US |
dc.contributor.author | Kosma, Veli-Matti | en_US |
dc.contributor.author | Koutros, Stella | en_US |
dc.contributor.author | Kraft, Peter | en_US |
dc.contributor.author | Kristensen, Vessela N. | en_US |
dc.contributor.author | Kurian, Allison W. | en_US |
dc.contributor.author | Lambrechts, Diether | en_US |
dc.contributor.author | Le Marchand, Loic | en_US |
dc.contributor.author | Linet, Martha | en_US |
dc.contributor.author | Lubiński, Jan | en_US |
dc.contributor.author | Mannermaa, Arto | en_US |
dc.contributor.author | Manoukian, Siranoush | en_US |
dc.contributor.author | Margolin, Sara | en_US |
dc.contributor.author | Martens, John W. M. | en_US |
dc.contributor.author | Mavroudis, Dimitrios | en_US |
dc.contributor.author | Mayes, Rebecca | en_US |
dc.contributor.author | Meindl, Alfons | en_US |
dc.contributor.author | Milne, Roger L. | en_US |
dc.contributor.author | Neuhausen, Susan L. | en_US |
dc.contributor.author | Nevanlinna, Heli | en_US |
dc.contributor.author | Newman, William G. | en_US |
dc.contributor.author | Nielsen, Sune F. | en_US |
dc.contributor.author | Nordestgaard, Børge G. | en_US |
dc.contributor.author | Obi, Nadia | en_US |
dc.contributor.author | Olshan, Andrew F. | en_US |
dc.contributor.author | Olson, Janet E. | en_US |
dc.contributor.author | Olsson, Håkan | en_US |
dc.contributor.author | Orban, Ester | en_US |
dc.contributor.author | Park-Simon, Tjoung-Won | en_US |
dc.contributor.author | Peterlongo, Paolo | en_US |
dc.contributor.author | Plaseska-Karanfilska, Dijana | en_US |
dc.contributor.author | Pylkäs, Katri | en_US |
dc.contributor.author | Rennert, Gad | en_US |
dc.contributor.author | Rennert, Hedy S. | en_US |
dc.contributor.author | Ruddy, Kathryn J. | en_US |
dc.contributor.author | Saloustros, Emmanouil | en_US |
dc.contributor.author | Sandler, Dale P. | en_US |
dc.contributor.author | Sawyer, Elinor J. | en_US |
dc.contributor.author | Schmutzler, Rita K. | en_US |
dc.contributor.author | Scott, Christopher | en_US |
dc.contributor.author | Shu, Xiao-Ou | en_US |
dc.contributor.author | Simard, Jacques | en_US |
dc.contributor.author | Smichkoska, Snezhana | en_US |
dc.contributor.author | Sohn, Christof | en_US |
dc.contributor.author | Southey, Melissa C. | en_US |
dc.contributor.author | Spinelli, John J. | en_US |
dc.contributor.author | Stone, Jennifer | en_US |
dc.contributor.author | Tamimi, Rulla M. | en_US |
dc.contributor.author | Taylor, Jack A. | en_US |
dc.contributor.author | Tollenaar, Rob A. E. M. | en_US |
dc.contributor.author | Tomlinson, Ian | en_US |
dc.contributor.author | Troester, Melissa A. | en_US |
dc.contributor.author | Truong, Thérèse | en_US |
dc.contributor.author | Vachon, Celine M. | en_US |
dc.contributor.author | van Veen, Elke M. | en_US |
dc.contributor.author | Wang, Sophia S. | en_US |
dc.contributor.author | Weinberg, Clarice R. | en_US |
dc.contributor.author | Wendt, Camilla | en_US |
dc.contributor.author | Wildiers, Hans | en_US |
dc.contributor.author | Winqvist, Robert | en_US |
dc.contributor.author | Wolk, Alicja | en_US |
dc.contributor.author | Zheng, Wei | en_US |
dc.contributor.author | Ziogas, Argyrios | en_US |
dc.contributor.author | Dunning, Alison M. | en_US |
dc.contributor.author | Pharoah, Paul D. P. | en_US |
dc.contributor.author | Easton, Douglas F. | en_US |
dc.contributor.author | Howie, A. Forbes | en_US |
dc.contributor.author | Peto, Julian | en_US |
dc.contributor.author | dos-Santos-Silva, Isabel | en_US |
dc.contributor.author | Swerdlow, Anthony J. | en_US |
dc.contributor.author | Chang-Claude, Jenny | en_US |
dc.contributor.author | Schmidt, Marjanka K. | en_US |
dc.contributor.author | Orr, Nick | en_US |
dc.contributor.author | Fletcher, Olivia | en_US |
dc.date.accessioned | 2021-01-27T11:19:25Z | - |
dc.date.available | 2021-01-27T11:19:25Z | - |
dc.date.issued | 2021-01-26 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/9955 | - |
dc.description.abstract | Background: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. Methods: We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry. Results: For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the <jats:italic>CYP3A</jats:italic> locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (−49.2%, 95% CI −56.1% to −41.1%, <jats:italic>P</jats:italic> = 3.1 × 10<jats:sup>–18</jats:sup>); in follow-up analyses, rs45446698-C was also associated with lower progesterone (−26.7%, 95% CI −39.4% to −11.6%, <jats:italic>P</jats:italic> = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82–0.91, P = 6.9 × 10. Conclusions The CYP3A7*1C</jats:italic> allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Nature and Cancer Research UK | en_US |
dc.relation.ispartof | British Journal of Cancer | en_US |
dc.title | CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s41416-020-01185-w | - |
dc.identifier.url | http://www.nature.com/articles/s41416-020-01185-w.pdf | - |
dc.identifier.url | http://www.nature.com/articles/s41416-020-01185-w | - |
dc.identifier.url | http://www.nature.com/articles/s41416-020-01185-w.pdf | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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