Dietary salt restriction accelerates atherosclerosis in apolipoprotein E-deficient mice

Ivanovski, Ognen; Szumilak, Dorota; Nguyen-Khoa, Thao; Dechaux, Michele; Massy, Ziad A; Phan, Olivier; Mothu, Nadya; Lacour, Bernard; Drueke, Tilman B; Muntzel, Martin

doi:10.1016/j.atherosclerosis.2004.12.020

Dietary salt restriction accelerates atherosclerosis in apolipoprotein E-deficient mice

Journal

Atherosclerosis

Date Issued

2005-06

Author(s)

Szumilak, Dorota

Nguyen-Khoa, Thao

Dechaux, Michele

Massy, Ziad A

Phan, Olivier

Mothu, Nadya

Lacour, Bernard

Drueke, Tilman B

Muntzel, Martin

DOI

10.1016/j.atherosclerosis.2004.12.020

Abstract

Whether a general reduction in salt intake reduces or actually enhances cardiovascular mortality in man remains an issue of controversy. Low sodium diets may lead to adverse side effects by stimulating the renin-angiotensin and sympathetic nervous systems. The present study was designed to investigate the effects of low dietary salt on atherosclerotic lesion progression in apolipoprotein E deficient (apoE(-/-)) mice.