The antioxidant N-acetylcysteine prevents accelerated atherosclerosis in uremic apolipoprotein E knockout mice

Ivanovski, Ognen; Szumilak, Dorota; Nguyen-Khoa, Thao; Ruellan, Nadya; Phan, Olivier; Lacour, Bernard; Descamps-Latscha, Béatrice; Drüeke, Tilman B; Massy, Ziad A

doi:10.1111/j.1523-1755.2005.00332.x

The antioxidant N-acetylcysteine prevents accelerated atherosclerosis in uremic apolipoprotein E knockout mice

Journal

Kidney international

Date Issued

2005-06

Author(s)

Szumilak, Dorota

Nguyen-Khoa, Thao

Ruellan, Nadya

Phan, Olivier

Lacour, Bernard

Descamps-Latscha, Béatrice

Drüeke, Tilman B

Massy, Ziad A

DOI

10.1111/j.1523-1755.2005.00332.x

Abstract

Cardiovascular disease is the most frequent cause of mortality in chronic renal failure (CRF). Therefore, it is important to identify appropriate treatment measures. The antioxidant N-acetylcysteine (NAC) has been shown to reduce cardiovascular events in hemodialysis patients. Here we examine a possible direct effect of NAC supplementation on uremia-enhanced atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice.