Calcification of the cavernosal bodies may be responsible for development of erectile dysfunction in uremic apolipoprotein E deficient (apoE-/-) mice

Ivanovski, Ognen; Nikolov, Igor G; Davceva, Olivera; Petrushevska, Gordana

doi:10.1016/j.androl.2019.08.002

Calcification of the cavernosal bodies may be responsible for development of erectile dysfunction in uremic apolipoprotein E deficient (apoE-/-) mice

Journal

Revista internacional de andrologia

Date Issued

2019-12-30

Author(s)

Davceva, Olivera

DOI

10.1016/j.androl.2019.08.002

Abstract

Erectile dysfunction's physiopathology in uremia is complex and multifactorial, involving a combination of classical risk factors and specific uremia-related risk factors such as increased oxidative stress, endothelial dysfunction and inflammation. The aim of the study is to investigate the effect of chronic kidney disease (CKD) on vascular calcification and endothelial function of cavernosal bodies in apolipoprotein E deficient (apoE-/-) mice, a well known model of erectile dysfunction.