Dosimetric evaluation of two intracavitary brachytherapy modalities in treatment of inoperable cervical cancer
Date Issued
2020-07-24
Author(s)
Lenche Kostadinova
Marija Simonovska
DOI
10.13140/RG.2.2.28757.04328
Abstract
Introduction. Brachytherapy comprises an integral part of inoperable cervical cancer definitive
treatment. Mostly used is intracavitary brachytherapy (ICB) with its primary role of boosting the total
dose needed for obtaining disease local control. ICB uses intra-uterine probe and ovoids/ring placed
inside the natural cavities combined with after-loading source placement in several applications
following external beam radiotherapy treatment (EBRT). Although three-dimensional (3D) ICB
planning is used, sometimes plans are calculated with two-dimensional planning (2D), especially
when shorter treatment time is needed due to various reasons.
Methods and materials. 20 patients were treated with ICB, with prior EBRT dose of 50.4Gy.
10 patients received high dose rate (HDR) ICB in three applications (once a week) with dose of
7Gy/weekly and total dose reaching 21Gy. 10 patients received their HDR ICB in two applications
with dose of 9Gy and total dose of 18Gy. All patients had 2D planning. Organ at risk (OAR)
constrains were adequate for 2D planning (70% of the prescribed dose for rectal points and 80% of
the prescribed dose for bladder point). Radiobiological equivalent for 2Gy daily dose
(EQD2, alpha/beta=10) for 3x7Gy ICB treatment is 29.8Gy and 28.5Gy for 2x9Gy ICB respectively.
Results. Organs at risk absorbed doses were evaluated in bladder and rectum. 2x9Gy ICB whole
treatment doses for rectum averaged at 4.04Gy, while doses for bladder averaged at 3.93Gy. 3x7Gy
ICB doses for rectum averaged at 3.47Gy and averaged at 2.57Gy for bladder.
Conclusion. OAR absorbed doses were comparable and both maintained the prescribed dose
constraints. Keeping in mind that three-dimensional (3D) ICB is the mainstay, yet in some situations
where patient conditions differ or when 3D planning resources are limited, both modalities
(2x9Gy and 3x7Gy) of 2D HDR ICB can be equally used successfully.
treatment. Mostly used is intracavitary brachytherapy (ICB) with its primary role of boosting the total
dose needed for obtaining disease local control. ICB uses intra-uterine probe and ovoids/ring placed
inside the natural cavities combined with after-loading source placement in several applications
following external beam radiotherapy treatment (EBRT). Although three-dimensional (3D) ICB
planning is used, sometimes plans are calculated with two-dimensional planning (2D), especially
when shorter treatment time is needed due to various reasons.
Methods and materials. 20 patients were treated with ICB, with prior EBRT dose of 50.4Gy.
10 patients received high dose rate (HDR) ICB in three applications (once a week) with dose of
7Gy/weekly and total dose reaching 21Gy. 10 patients received their HDR ICB in two applications
with dose of 9Gy and total dose of 18Gy. All patients had 2D planning. Organ at risk (OAR)
constrains were adequate for 2D planning (70% of the prescribed dose for rectal points and 80% of
the prescribed dose for bladder point). Radiobiological equivalent for 2Gy daily dose
(EQD2, alpha/beta=10) for 3x7Gy ICB treatment is 29.8Gy and 28.5Gy for 2x9Gy ICB respectively.
Results. Organs at risk absorbed doses were evaluated in bladder and rectum. 2x9Gy ICB whole
treatment doses for rectum averaged at 4.04Gy, while doses for bladder averaged at 3.93Gy. 3x7Gy
ICB doses for rectum averaged at 3.47Gy and averaged at 2.57Gy for bladder.
Conclusion. OAR absorbed doses were comparable and both maintained the prescribed dose
constraints. Keeping in mind that three-dimensional (3D) ICB is the mainstay, yet in some situations
where patient conditions differ or when 3D planning resources are limited, both modalities
(2x9Gy and 3x7Gy) of 2D HDR ICB can be equally used successfully.
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