CORRELATION BETWEEN SERUM LEVEL OF PLACENTAL GROWTH FACTOR IN FIRST TRIMESTER OF PREGNANCY AND SUBSEQUENT PREECLAMPSIA DEVELOPMENT - А PILOT STUDY

Abstract

Abstract Introduction. Preeclampsia (PE) is one of the leading causes for maternal and perinatal morbidity and mortality. The possibility of PE development prediction is essential for adequate management of this pathology, especially in terms of undertaken measures for disease prevention. Aim. To determine whether there is a correlation between serum levels of Placental Growth Factor (PlGF) in the first trimester of pregnancy with subsequent PE development. Methods. Study population was consisted of 307 pregnant women in the first trimester of pregnancy who had visited Special Hospital for Obstetrics and Gynecology “Mother Teresa” for aneuploidy screening. During this visit, blood was taken for measuring the PlGF level. The study was prospective-observational-cohort. All pregnant women were monitored for PE development until delivery. The group of pregnant women with PE was matched with that without disease by comparing PlGF values. Results. From the initial pool, only 283 participants completed the study. Among them, 7 developed PE. The average PlGF concentration in PE+ group was 32.29 pg/ml (1.06 MoM’s), and in PE-group 45.42 pg/ml (1.58 MoM’s). The difference between the results of the women destined to develop PE in comparison with those who are not, was statistically significant (0.018 and 0.011 for pg/ml and MoM’s respectively). Conclusion. Low serum level of PlGF in the first trimester of pregnancy is correlated with subsequent PE development.