Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/9067
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dc.contributor.authorJoksimovic, Nen_US
dc.contributor.authorSpasovski, Gen_US
dc.contributor.authorJoksimovic, Ven_US
dc.contributor.authorAndreevski, Ven_US
dc.contributor.authorZuccari, Cen_US
dc.contributor.authorOmini, C Fen_US
dc.date.accessioned2020-09-18T09:14:12Z-
dc.date.available2020-09-18T09:14:12Z-
dc.date.issued2012-09-
dc.identifier.issn2038-131X-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/9067-
dc.description.abstractTopical formulations are widely used in anti-haemorrhoidal treatment, but often lacking controlled clinical trials. Here, we report the results from a controlled clinical trial performed with a new gel medical device (Proctoial) containing hyaluronic acid with tea tree oil and methyl-sulfonyl-methane as major components. The total number of 36 haemorrhoidal patients (grade 1-3) was enrolled in a double-blind, placebo-controlled clinical trial and divided into 2 equal parallel groups. The anal pain, pain during defecation, visible bleeding, pruritus and irritation/inflammation were recorded before and after 14-day treatment using a visual analogue scale both by the investigators and by the patients. Safety and tolerability of the treatments were also recorded. The new gel medical device statistically significantly reduced all the symptoms after the treatment compared to placebo. The results indicated also a very good tolerability and safety of the treatments.en_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.ispartofUpdates in Surgeryen_US
dc.titleEfficacy and tolerability of hyaluronic acid, tea tree oil and methyl-sulfonyl-methane in a new gel medical device for treatment of haemorrhoids in a double-blind, placebo-controlled clinical trialen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s13304-012-0153-4-
dc.identifier.urlhttp://link.springer.com/content/pdf/10.1007/s13304-012-0153-4.pdf-
dc.identifier.urlhttp://link.springer.com/article/10.1007/s13304-012-0153-4/fulltext.html-
dc.identifier.urlhttp://link.springer.com/content/pdf/10.1007/s13304-012-0153-4-
dc.identifier.volume64-
dc.identifier.issue3-
dc.identifier.fpage195-
dc.identifier.lpage201-
item.fulltextNo Fulltext-
item.grantfulltextnone-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
Appears in Collections:Faculty of Medicine: Journal Articles
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