Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/8398
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Glavas-Dodov, Marija | en_US |
dc.contributor.author | Steffansen, Bente | en_US |
dc.contributor.author | Crcarevska, Maja S | en_US |
dc.contributor.author | Geskovski, Nikola | en_US |
dc.contributor.author | Dimchevska, Simona | en_US |
dc.contributor.author | Sonja Kuzmanovska | en_US |
dc.contributor.author | Goracinova, Katerina | en_US |
dc.date.accessioned | 2020-06-08T10:52:28Z | - |
dc.date.available | 2020-06-08T10:52:28Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/8398 | - |
dc.description.abstract | We have previously reported the development and characterisation of wheat germ agglutinin (WGA)-functionalised chitosan-Ca-alginate (CTS-Ca-ALG) microparticles (MPs) loaded with acid-resistant particles of 5-fluorouracil (5-FU). In the present work, our goal was to evaluate the potential of these carriers for efficient treatment of colon cancer by studying in vitro permeability and cell association of 5-FU and [methyl-³H]thymidine uptake in Caco-2 cells, as well as in vivo gastrointestinal distribution. The amount of 5-FU permeated through Caco-2 cells was 15.1, 7.7 and 6.5% for 5-FU solution, CTS-Ca-ALG MPs and WGA conjugates. The concentration of 5-FU associated with Caco-2 cells was significantly greater when delivered from MPs. By incorporation of 5-FU into MPs and further decoration with WGA, an increased [methyl-³H]thymidine uptake was observed few hours after continuous drug treatment followed by significantly reduced uptake after 6 h. Gastrointestinal distribution was in favour of increased localisation and concentration of the particles in colon region. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of microencapsulation | en_US |
dc.title | Wheat germ agglutinin-functionalised crosslinked polyelectrolyte microparticles for local colon delivery of 5-FU: in vitro efficacy and in vivo gastrointestinal distribution | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3109/02652048.2013.770099 | - |
dc.identifier.volume | 30 | - |
dc.identifier.issue | 7 | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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