Hyperhomocysteinemia in patients with coronary artery disease

Abstract

Aim: To determine the concentration of plasma homocysteine (Hcy) and the lipid risk factors: total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C) and triglycerides (TG) in patients with coronary artery disease (CAD) and healthy subjects, control group, as well as, to investigate the correlation between tHcy and lipid parameters in the set two groups of subjects.

Material and Methods: The investigation included 80 healthy subjects and 80 patients with CAD divided by gender. The concentration of Hcy was determined by the spectrophotometric cyclic enzymatic method, TC and TG and HDL-C were determined by standardized and routine enzymatic methods; LDL-C was calculated by the Friedewald’s formula.

Results: The concentration of Hcy were statistically significant higher in both sex with CAD compared to the control (p<0.001). The levels of lipids were statistically significant higher while HDL-C statistically significant lower in patients in comparison with control group (p<0.05). There were positive correlations between Hcy and TC, TG and LDL-C, and negative correlation between Hcy and HDL-C in group of men with CAD. Values for X2test (x2=35.48 and p <0.001) have showed a significant association between Hcy concentration and CAD. Increasing the concentration of tHcy for 1μmol/L, is leads to on increased risk for the occurrence of CAD for 25.2%.

Conclusion: The concentration of plasma Hcy is independent risk factor for occurance and development of CAD.