Please use this identifier to cite or link to this item:
Title: Acetaminophen Use and Risk of Asthma, Rhinoconjunctivitis, and Eczema in Adolescents
Authors: Beasley, Richard W.
Clayton, Tadd O.
Crane, Julian
Lai, Christopher K. W.
Montefort, Stephen R.
Mutius, Erika von
Stewart, Alistair W.
The ISAAC Phase Three Study Group
Vlaski, E 
Keywords: acetaminophen
Issue Date: 15-Jan-2011
Publisher: American Thoracic Society
Project: International Study ofAsthma and Allergies in Childhood (ISAAC) Phase Three
Journal: American Journal of Respiratory and Critical Care Medicine
Abstract: Rationale: There is epidemiological evidence that the use of acetaminophen may increase the risk of developing asthma. Objectives: To investigate the risk of asthma and other allergic disorders associated with the current use of acetaminophen in 13- to 14-year-old children in different populations worldwide. Methods :As part of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three, 13- to 14-year-old children completed written and video questionnaires obtaining data on current symptoms of asthma, rhinoconjunctivitis, and eczema, and a written environmental questionnaire obtaining dataon putative risk factors, including acetaminophen use in the past 12 months. Measurements and Main Results: The primary outcome measure was the odds ratio (OR) of current asthma symptoms associated with acetaminophen use calculated by logistic regression. A total of 322,959 adolescent children from 113 centers in 50 countries participated. In the multivariate analyses the recent use of acetaminophen was associated with an exposure-dependent increased risk of current asthmasymptoms(OR, 1.43 [95%confidenceinterval, 1.33–1.53] and 2.51 [95% confidence interval, 2.33–2.70] for medium and high versus no use, respectively). Acetaminophen use was also associated with an exposure-dependent increased risk of current symptoms of rhinoconjunctivitis and eczema. Conclusions: Acetaminophen use may represent an important risk factor for the development and/or maintenance of asthma, rhinoconjunctivitis, and eczema in adolescent children.
DOI: 10.1164/rccm.201005-0757oc
Appears in Collections:Faculty of Medicine: Journal Articles

Files in This Item:
File Description SizeFormat 
rccm.201005-0757oc.pdf1.43 MBAdobe PDFThumbnail
Show full item record

Page view(s)

checked on Jul 14, 2020


checked on Jul 14, 2020

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.