Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/7382
DC Field | Value | Language |
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dc.contributor.author | Fachal, Laura | en_US |
dc.contributor.author | Aschard, Hugues | en_US |
dc.contributor.author | Beesley, Jonathan | en_US |
dc.contributor.author | Barnes, Daniel R | en_US |
dc.contributor.author | Allen, Jamie | en_US |
dc.contributor.author | Kar, Siddhartha | en_US |
dc.contributor.author | Pooley, Karen A | en_US |
dc.contributor.author | Dennis, Joe | en_US |
dc.contributor.author | Michailidou, Kyriaki | en_US |
dc.contributor.author | Turman, Constance | en_US |
dc.contributor.author | Soucy, Penny | en_US |
dc.contributor.author | Lindblom, Annika | en_US |
dc.contributor.author | Lo, Wing-Yee | en_US |
dc.contributor.author | Long, Jirong | en_US |
dc.contributor.author | Lophatananon, Artitaya | en_US |
dc.contributor.author | Loud, Jennifer T | en_US |
dc.contributor.author | Lubiński, Jan | en_US |
dc.contributor.author | MacInnis, Robert J | en_US |
dc.contributor.author | Maishman, Tom | en_US |
dc.contributor.author | Makalic, Enes | en_US |
dc.contributor.author | Alonso, M Rosario | en_US |
dc.contributor.author | Friedman, Eitan | en_US |
dc.contributor.author | Mannermaa, Arto | en_US |
dc.contributor.author | Manoochehri, Mehdi | en_US |
dc.contributor.author | Manoukian, Siranoush | en_US |
dc.contributor.author | Margolin, Sara | en_US |
dc.contributor.author | Martinez, Maria Elena | en_US |
dc.contributor.author | Matsuo, Keitaro | en_US |
dc.contributor.author | Maurer, Tabea | en_US |
dc.contributor.author | Mavroudis, Dimitrios | en_US |
dc.contributor.author | Mayes, Rebecca | en_US |
dc.contributor.author | McGuffog, Lesley | en_US |
dc.contributor.author | Fritschi, Lin | en_US |
dc.contributor.author | Andrulis, Irene L | en_US |
dc.contributor.author | McLean, Catriona | en_US |
dc.contributor.author | Mebirouk, Noura | en_US |
dc.contributor.author | Meindl, Alfons | en_US |
dc.contributor.author | Miller, Austin | en_US |
dc.contributor.author | Miller, Nicola | en_US |
dc.contributor.author | Montagna, Marco | en_US |
dc.contributor.author | Moreno, Fernando | en_US |
dc.contributor.author | Muir, Kenneth | en_US |
dc.contributor.author | Mulligan, Anna Marie | en_US |
dc.contributor.author | Frost, Debra | en_US |
dc.contributor.author | Muñoz-Garzon, Victor M | en_US |
dc.contributor.author | Anton-Culver, Hoda | en_US |
dc.contributor.author | Muranen, Taru A | en_US |
dc.contributor.author | Narod, Steven A | en_US |
dc.contributor.author | Nassir, Rami | en_US |
dc.contributor.author | Nathanson, Katherine L | en_US |
dc.contributor.author | Neuhausen, Susan L | en_US |
dc.contributor.author | Nevanlinna, Heli | en_US |
dc.contributor.author | Neven, Patrick | en_US |
dc.contributor.author | Nielsen, Finn C | en_US |
dc.contributor.author | Gabrielson, Marike | en_US |
dc.contributor.author | Nikitina-Zake, Liene | en_US |
dc.contributor.author | Norman, Aaron | en_US |
dc.contributor.author | Antonenkova, Natalia N | en_US |
dc.contributor.author | Offit, Kenneth | en_US |
dc.contributor.author | Olah, Edith | en_US |
dc.contributor.author | Olopade, Olufunmilayo I | en_US |
dc.contributor.author | Olsson, Håkan | en_US |
dc.contributor.author | Orr, Nick | en_US |
dc.contributor.author | Osorio, Ana | en_US |
dc.contributor.author | Pankratz, V Shane | en_US |
dc.contributor.author | Gago-Dominguez, Manuela | en_US |
dc.contributor.author | Papp, Janos | en_US |
dc.contributor.author | Park, Sue K | en_US |
dc.contributor.author | Park-Simon, Tjoung-Won | en_US |
dc.contributor.author | Arason, Adalgeir | en_US |
dc.contributor.author | Parsons, Michael T | en_US |
dc.contributor.author | Paul, James | en_US |
dc.contributor.author | Pedersen, Inge Sokilde | en_US |
dc.contributor.author | Peissel, Bernard | en_US |
dc.contributor.author | Peshkin, Beth | en_US |
dc.contributor.author | Peterlongo, Paolo | en_US |
dc.contributor.author | Gambino, Gaetana | en_US |
dc.contributor.author | Peto, Julian | en_US |
dc.contributor.author | Plaseska-Karanfilska, Dijana | en_US |
dc.contributor.author | Prajzendanc, Karolina | en_US |
dc.contributor.author | Prentice, Ross | en_US |
dc.contributor.author | Arndt, Volker | en_US |
dc.contributor.author | Presneau, Nadege | en_US |
dc.contributor.author | Prokofyeva, Darya | en_US |
dc.contributor.author | Pujana, Miquel Angel | en_US |
dc.contributor.author | Pylkäs, Katri | en_US |
dc.contributor.author | Radice, Paolo | en_US |
dc.contributor.author | Ganz, Patricia A | en_US |
dc.contributor.author | Ramus, Susan J | en_US |
dc.contributor.author | Rantala, Johanna | en_US |
dc.contributor.author | Rau-Murthy, Rohini | en_US |
dc.contributor.author | Rennert, Gad | en_US |
dc.contributor.author | Risch, Harvey A | en_US |
dc.contributor.author | Aronson, Kristan J | en_US |
dc.contributor.author | Robson, Mark | en_US |
dc.contributor.author | Romero, Atocha | en_US |
dc.contributor.author | Rossing, Maria | en_US |
dc.contributor.author | Saloustros, Emmanouil | en_US |
dc.contributor.author | Gapstur, Susan M | en_US |
dc.contributor.author | Sánchez-Herrero, Estela | en_US |
dc.contributor.author | Sandler, Dale P | en_US |
dc.contributor.author | Santamariña, Marta | en_US |
dc.contributor.author | Saunders, Christobel | en_US |
dc.contributor.author | Sawyer, Elinor J | en_US |
dc.contributor.author | Scheuner, Maren T | en_US |
dc.contributor.author | Arun, Banu K | en_US |
dc.contributor.author | Schmidt, Daniel F | en_US |
dc.contributor.author | Schmutzler, Rita K | en_US |
dc.contributor.author | Schneeweiss, Andreas | en_US |
dc.contributor.author | Garber, Judy | en_US |
dc.contributor.author | Schoemaker, Minouk J | en_US |
dc.contributor.author | Schöttker, Ben | en_US |
dc.contributor.author | Schürmann, Peter | en_US |
dc.contributor.author | Scott, Christopher | en_US |
dc.contributor.author | Scott, Rodney J | en_US |
dc.contributor.author | Senter, Leigha | en_US |
dc.contributor.author | Seynaeve, Caroline M | en_US |
dc.contributor.author | Auber, Bernd | en_US |
dc.contributor.author | Shah, Mitul | en_US |
dc.contributor.author | Sharma, Priyanka | en_US |
dc.contributor.author | García-Sáenz, José A | en_US |
dc.contributor.author | Shen, Chen-Yang | en_US |
dc.contributor.author | Shu, Xiao-Ou | en_US |
dc.contributor.author | Singer, Christian F | en_US |
dc.contributor.author | Slavin, Thomas P | en_US |
dc.contributor.author | Smichkoska, Snezhana | en_US |
dc.contributor.author | Southey, Melissa C | en_US |
dc.contributor.author | Spinelli, John J | en_US |
dc.contributor.author | Spurdle, Amanda B | en_US |
dc.contributor.author | Auer, Paul L | en_US |
dc.contributor.author | Stone, Jennifer | en_US |
dc.contributor.author | Lemaçon, Audrey | en_US |
dc.contributor.author | Stoppa-Lyonnet, Dominique | en_US |
dc.contributor.author | Sutter, Christian | en_US |
dc.contributor.author | Swerdlow, Anthony J | en_US |
dc.contributor.author | Tamimi, Rulla M | en_US |
dc.contributor.author | Tan, Yen Yen | en_US |
dc.contributor.author | Tapper, William J | en_US |
dc.contributor.author | Taylor, Jack A | en_US |
dc.contributor.author | Teixeira, Manuel R | en_US |
dc.contributor.author | Tengström, Maria | en_US |
dc.contributor.author | Azzollini, Jacopo | en_US |
dc.contributor.author | Gaudet, Mia M | en_US |
dc.contributor.author | Teo, Soo Hwang | en_US |
dc.contributor.author | Terry, Mary Beth | en_US |
dc.contributor.author | Teulé, Alex | en_US |
dc.contributor.author | Thomassen, Mads | en_US |
dc.contributor.author | Thull, Darcy L | en_US |
dc.contributor.author | Tischkowitz, Marc | en_US |
dc.contributor.author | Toland, Amanda E | en_US |
dc.contributor.author | Tollenaar, Rob A E M | en_US |
dc.contributor.author | Tomlinson, Ian | en_US |
dc.contributor.author | Torres, Diana | en_US |
dc.contributor.author | Georgoulias, Vassilios | en_US |
dc.contributor.author | Balmaña, Judith | en_US |
dc.contributor.author | Torres-Mejía, Gabriela | en_US |
dc.contributor.author | Troester, Melissa A | en_US |
dc.contributor.author | Truong, Thérèse | en_US |
dc.contributor.author | Tung, Nadine | en_US |
dc.contributor.author | Tzardi, Maria | en_US |
dc.contributor.author | Ulmer, Hans-Ulrich | en_US |
dc.contributor.author | Vachon, Celine M | en_US |
dc.contributor.author | van Asperen, Christi J | en_US |
dc.contributor.author | van der Kolk, Lizet E | en_US |
dc.contributor.author | Giles, Graham G | en_US |
dc.contributor.author | van Rensburg, Elizabeth J | en_US |
dc.contributor.author | Barkardottir, Rosa B | en_US |
dc.contributor.author | Vega, Ana | en_US |
dc.contributor.author | Viel, Alessandra | en_US |
dc.contributor.author | Vijai, Joseph | en_US |
dc.contributor.author | Vogel, Maartje J | en_US |
dc.contributor.author | Wang, Qin | en_US |
dc.contributor.author | Wappenschmidt, Barbara | en_US |
dc.contributor.author | Weinberg, Clarice R | en_US |
dc.contributor.author | Weitzel, Jeffrey N | en_US |
dc.contributor.author | Glendon, Gord | en_US |
dc.contributor.author | Wendt, Camilla | en_US |
dc.contributor.author | Wildiers, Hans | en_US |
dc.contributor.author | Barrowdale, Daniel | en_US |
dc.contributor.author | Winqvist, Robert | en_US |
dc.contributor.author | Wolk, Alicja | en_US |
dc.contributor.author | Wu, Anna H | en_US |
dc.contributor.author | Yannoukakos, Drakoulis | en_US |
dc.contributor.author | Zhang, Yan | en_US |
dc.contributor.author | Zheng, Wei | en_US |
dc.contributor.author | Hunter, David | en_US |
dc.contributor.author | Godwin, Andrew K | en_US |
dc.contributor.author | Pharoah, Paul D P | en_US |
dc.contributor.author | Chang-Claude, Jenny | en_US |
dc.contributor.author | García-Closas, Montserrat | en_US |
dc.contributor.author | Beeghly-Fadiel, Alicia | en_US |
dc.contributor.author | Schmidt, Marjanka K | en_US |
dc.contributor.author | Milne, Roger L | en_US |
dc.contributor.author | Kristensen, Vessela N | en_US |
dc.contributor.author | French, Juliet D | en_US |
dc.contributor.author | Edwards, Stacey L | en_US |
dc.contributor.author | Antoniou, Antonis C | en_US |
dc.contributor.author | Goldberg, Mark S | en_US |
dc.contributor.author | Chenevix-Trench, Georgia | en_US |
dc.contributor.author | Simard, Jacques | en_US |
dc.contributor.author | Easton, Douglas F | en_US |
dc.contributor.author | Kraft, Peter | en_US |
dc.contributor.author | Benitez, Javier | en_US |
dc.contributor.author | Dunning, Alison M | en_US |
dc.contributor.author | Bermisheva, Marina | en_US |
dc.contributor.author | Białkowska, Katarzyna | en_US |
dc.contributor.author | Blanco, Amie M | en_US |
dc.contributor.author | Blomqvist, Carl | en_US |
dc.contributor.author | Goldgar, David E | en_US |
dc.contributor.author | Blot, William | en_US |
dc.contributor.author | Bogdanova, Natalia V | en_US |
dc.contributor.author | Bojesen, Stig E | en_US |
dc.contributor.author | Bolla, Manjeet K | en_US |
dc.contributor.author | Bonanni, Bernardo | en_US |
dc.contributor.author | Borg, Ake | en_US |
dc.contributor.author | Bosse, Kristin | en_US |
dc.contributor.author | Brauch, Hiltrud | en_US |
dc.contributor.author | Brenner, Hermann | en_US |
dc.contributor.author | Briceno, Ignacio | en_US |
dc.contributor.author | González-Neira, Anna | en_US |
dc.contributor.author | Brock, Ian W | en_US |
dc.contributor.author | Brooks-Wilson, Angela | en_US |
dc.contributor.author | Brüning, Thomas | en_US |
dc.contributor.author | Burwinkel, Barbara | en_US |
dc.contributor.author | Buys, Saundra S | en_US |
dc.contributor.author | Cai, Qiuyin | en_US |
dc.contributor.author | Caldés, Trinidad | en_US |
dc.contributor.author | Caligo, Maria A | en_US |
dc.contributor.author | Camp, Nicola J | en_US |
dc.contributor.author | Campbell, Ian | en_US |
dc.contributor.author | Tibiletti, Maria Grazia | en_US |
dc.contributor.author | Canzian, Federico | en_US |
dc.contributor.author | Carroll, Jason S | en_US |
dc.contributor.author | Carter, Brian D | en_US |
dc.contributor.author | Castelao, Jose E | en_US |
dc.contributor.author | Chiquette, Jocelyne | en_US |
dc.contributor.author | Christiansen, Hans | en_US |
dc.contributor.author | Chung, Wendy K | en_US |
dc.contributor.author | Claes, Kathleen B M | en_US |
dc.contributor.author | Clarke, Christine L | en_US |
dc.contributor.author | Collée, J Margriet | en_US |
dc.contributor.author | Greene, Mark H | en_US |
dc.contributor.author | Cornelissen, Sten | en_US |
dc.contributor.author | Couch, Fergus J | en_US |
dc.contributor.author | Cox, Angela | en_US |
dc.contributor.author | Cross, Simon S | en_US |
dc.contributor.author | Cybulski, Cezary | en_US |
dc.contributor.author | Czene, Kamila | en_US |
dc.contributor.author | Daly, Mary B | en_US |
dc.contributor.author | de la Hoya, Miguel | en_US |
dc.contributor.author | Devilee, Peter | en_US |
dc.contributor.author | Diez, Orland | en_US |
dc.contributor.author | Lush, Michael | en_US |
dc.contributor.author | Ding, Yuan Chun | en_US |
dc.contributor.author | Dite, Gillian S | en_US |
dc.contributor.author | Domchek, Susan M | en_US |
dc.contributor.author | Dörk, Thilo | en_US |
dc.contributor.author | Dos-Santos-Silva, Isabel | en_US |
dc.contributor.author | Droit, Arnaud | en_US |
dc.contributor.author | Dubois, Stéphane | en_US |
dc.contributor.author | Dumont, Martine | en_US |
dc.contributor.author | Duran, Mercedes | en_US |
dc.contributor.author | Durcan, Lorraine | en_US |
dc.contributor.author | Grip, Mervi | en_US |
dc.contributor.author | Dwek, Miriam | en_US |
dc.contributor.author | Eccles, Diana M | en_US |
dc.contributor.author | Engel, Christoph | en_US |
dc.contributor.author | Eriksson, Mikael | en_US |
dc.contributor.author | Evans, D Gareth | en_US |
dc.contributor.author | Fasching, Peter A | en_US |
dc.contributor.author | Fletcher, Olivia | en_US |
dc.contributor.author | Floris, Giuseppe | en_US |
dc.contributor.author | Flyger, Henrik | en_US |
dc.contributor.author | Foretova, Lenka | en_US |
dc.contributor.author | Gronwald, Jacek | en_US |
dc.contributor.author | Foulkes, William D | en_US |
dc.contributor.author | Grundy, Anne | en_US |
dc.contributor.author | Guénel, Pascal | en_US |
dc.contributor.author | Hahnen, Eric | en_US |
dc.contributor.author | Haiman, Christopher A | en_US |
dc.contributor.author | Håkansson, Niclas | en_US |
dc.contributor.author | Hall, Per | en_US |
dc.contributor.author | Hamann, Ute | en_US |
dc.contributor.author | Harrington, Patricia A | en_US |
dc.contributor.author | Tyrer, Jonathan P | en_US |
dc.contributor.author | Hartikainen, Jaana M | en_US |
dc.contributor.author | Hartman, Mikael | en_US |
dc.contributor.author | He, Wei | en_US |
dc.contributor.author | Healey, Catherine S | en_US |
dc.contributor.author | Heemskerk-Gerritsen, Bernadette A M | en_US |
dc.contributor.author | Heyworth, Jane | en_US |
dc.contributor.author | Hillemanns, Peter | en_US |
dc.contributor.author | Hogervorst, Frans B L | en_US |
dc.contributor.author | Hollestelle, Antoinette | en_US |
dc.contributor.author | Hooning, Maartje J | en_US |
dc.contributor.author | Ghoussaini, Maya | en_US |
dc.contributor.author | Hopper, John L | en_US |
dc.contributor.author | Howell, Anthony | en_US |
dc.contributor.author | Huang, Guanmengqian | en_US |
dc.contributor.author | Hulick, Peter J | en_US |
dc.contributor.author | Imyanitov, Evgeny N | en_US |
dc.contributor.author | Isaacs, Claudine | en_US |
dc.contributor.author | Iwasaki, Motoki | en_US |
dc.contributor.author | Jager, Agnes | en_US |
dc.contributor.author | Jakimovska, Milena | en_US |
dc.contributor.author | Jakubowska, Anna | en_US |
dc.contributor.author | Moradi Marjaneh, Mahdi | en_US |
dc.contributor.author | James, Paul A | en_US |
dc.contributor.author | Janavicius, Ramunas | en_US |
dc.contributor.author | Jankowitz, Rachel C | en_US |
dc.contributor.author | John, Esther M | en_US |
dc.contributor.author | Johnson, Nichola | en_US |
dc.contributor.author | Jones, Michael E | en_US |
dc.contributor.author | Jukkola-Vuorinen, Arja | en_US |
dc.contributor.author | Jung, Audrey | en_US |
dc.contributor.author | Kaaks, Rudolf | en_US |
dc.contributor.author | Kang, Daehee | en_US |
dc.contributor.author | Jiang, Xia | en_US |
dc.contributor.author | Kapoor, Pooja Middha | en_US |
dc.contributor.author | Karlan, Beth Y | en_US |
dc.contributor.author | Keeman, Renske | en_US |
dc.contributor.author | Kerin, Michael J | en_US |
dc.contributor.author | Khusnutdinova, Elza | en_US |
dc.contributor.author | Kiiski, Johanna I | en_US |
dc.contributor.author | Kirk, Judy | en_US |
dc.contributor.author | Kitahara, Cari M | en_US |
dc.contributor.author | Ko, Yon-Dschun | en_US |
dc.contributor.author | Konstantopoulou, Irene | en_US |
dc.contributor.author | Agata, Simona | en_US |
dc.contributor.author | Kosma, Veli-Matti | en_US |
dc.contributor.author | Koutros, Stella | en_US |
dc.contributor.author | Kubelka-Sabit, Katerina | en_US |
dc.contributor.author | Kwong, Ava | en_US |
dc.contributor.author | Kyriacou, Kyriacos | en_US |
dc.contributor.author | Laitman, Yael | en_US |
dc.contributor.author | Lambrechts, Diether | en_US |
dc.contributor.author | Lee, Eunjung | en_US |
dc.contributor.author | Leslie, Goska | en_US |
dc.contributor.author | Lester, Jenny | en_US |
dc.contributor.author | Aittomäki, Kristiina | en_US |
dc.contributor.author | Lesueur, Fabienne | en_US |
dc.date.accessioned | 2020-03-25T11:30:20Z | - |
dc.date.available | 2020-03-25T11:30:20Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/7382 | - |
dc.description.abstract | Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a Bayesian approach (PAINTOR) that combines genetic association, linkage disequilibrium and enriched genomic features to determine variants with high posterior probabilities of being causal. Potentially causal variants were significantly over-represented in active gene regulatory regions and transcription factor binding sites. We applied our INQUSIT pipeline for prioritizing genes as targets of those potentially causal variants, using gene expression (expression quantitative trait loci), chromatin interaction and functional annotations. Known cancer drivers, transcription factors and genes in the developmental, apoptosis, immune system and DNA integrity checkpoint gene ontology pathways were over-represented among the highest-confidence target genes. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Science and Business Media LLC | en_US |
dc.relation.ispartof | Nature Genetics | en_US |
dc.title | Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s41588-019-0537-1 | - |
dc.identifier.url | http://www.nature.com/articles/s41588-019-0537-1.pdf | - |
dc.identifier.url | http://www.nature.com/articles/s41588-019-0537-1 | - |
dc.identifier.url | http://www.nature.com/articles/s41588-019-0537-1.pdf | - |
dc.identifier.volume | 52 | - |
dc.identifier.issue | 1 | - |
dc.identifier.fpage | 56 | - |
dc.identifier.lpage | 73 | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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