Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/6344
Title: Characterization and Epidemiology of Pigeon Paramyxovirus Type-1 Viruses (PPMV-1) Isolated in Macedonia
Authors: Dodovski, Aleksandar 
Cvetkovikj, Iskra 
Krstevski, Kiril 
Naletoski, I.
Savić, Vladimir
Keywords: pigeon paramyxovirus type 1, pigeon, characterization, phylogeny, epidemiology, Macedonia
Issue Date: Jun-2017
Publisher: American Association of Avian Pathologists (AAAP)
Journal: Avian Diseases
Abstract: We have characterized in this study 10 PPMV-1 isolated from domestic pigeons and one PPMV-1 isolated from a feral pigeon in the period 2007–2012, using both classical methods (HI test and ICPI test) and molecular methods (RT-qPCR, RT-PCR, and nucleotide sequencing). Using phylogenetic analysis of partial fusion gene sequences, these viruses clustered with recent European PPMV-1 isolates (EU/re) within the genotype VIb/1. All isolates possessed virulent cleavage site motifs with variable morbidity and mortality in pigeons. The intracerebral pathogenecity indices of the five isolates ranged from 0.59 to 1.53. The repetitive isolation of PPMV-1 viruses for several consecutive years led toward establishing enzootic presence of the disease in pigeons. A high nucleotide sequence homology between the Macedonian isolates and EU/re isolates was shown. Co-circulation of different isolates in the same holdings was detected. This is the first study to extensively describe the molecular epidemiology of PPMV-1 isolated in Macedonia.
URI: http://hdl.handle.net/20.500.12188/6344
DOI: 10.1637/11517-101816-reg.1
Appears in Collections:Faculty of Veterinary Medicine: Journal Articles

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