Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/33481
Title: Salivary Markers in Patients with Chronic Kidney Disease
Authors: Poposki, Bojan
Ivanovski, Kiro 
Stefanova, Renata
Dirjanska, Katarina 
Rambabova Bushljetic, Irena 
Ristovski, Vangel 
Risteska, Nada
Keywords: saliva
urea
creatinine
kidney failure
chronic
Issue Date: 1-Jul-2023
Publisher: Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH
Journal: Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) 
Abstract: Aim of the study: To determine the possibility of using saliva as a diagnostic and prognostic tool for screening and monitoring kidney function. Methods: This study included 32 patients with different stages of chronic kidney disease (CKD) and 20 healthy examinees for the control group. Saliva was collected using the spitting method, and on the same day blood was also drawn from the examinees to determine serum concentrations of urea and creatinine. The salivary values of uric acid, urea, creatinine and albumin were determined with a spectrophotometer, as well as the serum concentrations of urea and creatinine. Results: Our results showed a statistically significant positive correlation between salivary and serum levels of urea and creatinine in patients with CKD (Pearson's correlation coefficient for urea was r =0.6527, p = 0.000, while for creatinine it was r = 0.5486, p = 0.001). We detected a statistically significant positive correlation between the salivary levels of urea and the clinical stage of CKD (r = 0.4667, p = 0.007). We did not register a significant correlation between the salivary levels of creatinine and the clinical stage of CKD (r = 0.1643, p = 0.369). Conclusion: Salivary urea is a valid marker for determining kidney function and a potential salivary marker for screening and monitoring kidney function. Salivary creatinine can be used as a qualitative marker, only indicating the existence of a disease.
URI: http://hdl.handle.net/20.500.12188/33481
DOI: 10.2478/prilozi-2023-0033
Appears in Collections:Faculty of Medicine: Journal Articles

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