Comparison of HOMA-IR, Tg/Glucose Index and Tg/HDL-C ratio for predicating Metabolic Sy in HCV seronegative heroin dependents

Abstract

Metabolic syndrome (MetSy) with insulin resistance was represented, although in lesser extend, in heroin dependents as well as in general population1. Recent studies showed that patients on methadone substitution had a worse metabolic profile compared to buprenorphine2. The quick and easy detection of MetS in heroin addicts is important not only as a metabolic and cardiovascular risk factor, but also as an indicator for recommending a substitution program. The study aims to compare the predictive power of surrogate markers such as Triglyceride-Glucose (TgG) index, HOMA-IR and Triglyceride/HDL-C ratio (Tg/HDL-C) for easier detecting MetSy in heroin dependents.