"DEVELOPMENTAL HEMOSTASIS" AND PEDIATRIC SURGERY
Journal
Macedonian Journal of Anesthesia
Date Issued
2023-12
Author(s)
Nancheva Bogoevska, Andrea
Abstract
Hemostasis can be defined as a physiological process that stops bleeding after injury of blood
vessels. It is a complex and highly regulated process to localize the blood clot only to the site of
injury. The hemostatic system in the human body is based on the components of Virchow’s triad:
1. vascular injury, 2. change in blood coagulability, 3. disturbance of blood flow (stasis).
If the third component (blood flow) is excluded, hemostasis can be defined as an inter-reaction
between the blood vessel wall, blood cell components and plasma proteins that maintain the hemostatic balance. The final outcome of hemostasis is coagulation of blood at the site of vascular
injury(1,3). Hemostasis can be divided into primary, secondary and tertiary hemostasis. These three independent mechanisms combine to maintain hemostatic balance.
vessels. It is a complex and highly regulated process to localize the blood clot only to the site of
injury. The hemostatic system in the human body is based on the components of Virchow’s triad:
1. vascular injury, 2. change in blood coagulability, 3. disturbance of blood flow (stasis).
If the third component (blood flow) is excluded, hemostasis can be defined as an inter-reaction
between the blood vessel wall, blood cell components and plasma proteins that maintain the hemostatic balance. The final outcome of hemostasis is coagulation of blood at the site of vascular
injury(1,3). Hemostasis can be divided into primary, secondary and tertiary hemostasis. These three independent mechanisms combine to maintain hemostatic balance.
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