Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/31105
DC Field | Value | Language |
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dc.contributor.author | Sima, Aneta | en_US |
dc.contributor.author | Simeonova krstevska, Slagjana | en_US |
dc.contributor.author | Dabeski, Drage | en_US |
dc.contributor.author | Livrinova, Vesna | en_US |
dc.date.accessioned | 2024-07-26T11:36:28Z | - |
dc.date.available | 2024-07-26T11:36:28Z | - |
dc.date.issued | 2024-02-25 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/31105 | - |
dc.description.abstract | <jats:p>Introduction: Perimenopause as a clinical entity is characterized by a series of symptoms that occur due to estrogen deficiency in multiple organs and systems. Obesity is a risk factor that favors all these changes, especially hyperplasia. Glucose homeostasis is often impaired in these patients, insulin levels are increased, and HOMA IR is increased. Goals: to detect hyperplasia in obese perimenopausal patients with abnormal uterine bleeding to determine insulin levels, HOMA IR, to determine the association between hyperplasia and HOMA IR. Material and Methods: This was a prospective cohort study, performed at the OB/GYN Clinic, over 1 year. 100 patients with abnormal uterine bleeding during the perimenopause were involved, aged 45–50, divided into two groups based on BMI. 1-patients with a BMI above 30, 2-patients with a BMI under 30, and the control group consisted of 40 asymptomatic patients. Results: The average value of glycemia in the first group was higher and was 5.7 mmol/l, the cut-off value was 5,5. The average value of the HOMA-IR insulin resistance index in the first group was highest - 2.8 (the cut-off value was 1.8). Endometrial hyperplasia was registered in the first group at 40.9%. Discussion: The first group registered a significant association between HOMA IR and hyperplasia, the risk of endometrial hyperplasia occurring was eight times higher. The first group registered a significant association between glycemia and endometrial hyperplasia. High levels of glycemia increase the risk of endometrial hyperplasia occurring three times. Conclusion: In menopausal transition patients with abnormal uterine bleeding there is an increased incidence of endometrial hyperplasia, hyperglycemia, and increased HOMA IR. There is a strong association between these changes and the risk of cardiovascular disease increases. Menopause is a period in a woman’s life that requires a multidisciplinary approach to diagnostics and treatment. Keywords: HOMA IR, perimenopause, abnormal bleeding, hyperplasia.</jats:p> | en_US |
dc.publisher | MSD Publications India Pvt Ltd. | en_US |
dc.relation.ispartof | Research International Journal of Obstetrics and Gynecology | en_US |
dc.title | Evaluation of HOMA IR in perimenopause patients with abnormal uterine bleeding | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.37179/rijog.000002 | - |
dc.identifier.volume | 02 | - |
dc.identifier.issue | 01 | - |
dc.identifier.fpage | 001 | - |
dc.identifier.lpage | 004 | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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