CORRELATION BETWEEN SFLT/PLGF RATIO HIGHER THAN 200 AND ALTERED LABORATORY PARAMETARS OF PREECLAMPSIA IN HOSPITAL SETTINGS PATIENTS

Abstract

Preeclampsia affects 2–7% of all pregnancies. Worldwide it is responsible for 500,000 fetal/neonatal deaths and 70,000 maternal deaths every year. Anti-angiogenic factor, soluble fms-like tyrosine kinase 1 (sFlt-1) and the pro-angiogenic factor, placental growth factor (PlGF) are usefull markers for screening, diagnosis and prognosis of preeclampsia. Aim: To show our experience about the correlation between angiogenic levels and laboratory blood and urine parametars in hospital settings patients with preeclampsia. Material and methods : Retrospective clinical study was performed in 2 years period. One hundred pregnant women with preeclampsia hospitalized in University clinic for obstetrics and gynecology in peripartal intensive care unite were evaluated .SFLT/PLGF ratio (Elecsys sFlt-1 and PlGF immunoassays), differential blood count, AST, ALT, LDH, uric acid, urine analysis (qualitative, quantitative proteinuria) were evaluated in all patients. Questionaire about sociodemographic data, age, parity, BMI, poor obstetric history, cigarette smoking, use of Aspirin or Clexane during actual pregnancy was taken during admission. Related to the sFlt-1/PIGF ratio (< 200 or ≥ 200) women were divided into two groups with 50% participants each. Results: Our patients with SFLT/PLGF ratio >200 were significantly younger, had significantly higher proteinuria (++,+++ and quantitative), had significantly higher levels of LDH and AST and were admitted at hospital treatment at significantly lower gestational week compared to ratio < 200.