COVID-19 IN CHILDREN WITH DOWN SYNDROME-CASE SERIES

Abstract

Down syndrome (DS) is the most common genetic disease and presents withcognitive impairment, cardiac and gastrointestinal abnormalities, increasedrisk of hematological malignancy and several autoimmune conditions in additionto other miscellaneous clinical conditionsThe aim is to show if the comorbidities that children with Down Sy have, were risk factors for more severe form of COVID-19.We present three cases of children with Down Sy and COVID-19, with different clinical features. All of them had good clinical outcome, only the firstchild had more severe form of Covid 19 with needfor oxygen support, longer hospitalization but with good clinical improvement and withdrawal of the X-ray changes. Children with Down Sy are always a high-risk group for more severeand prolonged course of disease, which are partiallyattributed to defects of the immune system.