Синдром на несоодветно лачење на антидиуретски хормон - честа непрепознаена причина за хипонатремија

Abstract

Hyponatremia is the most common electrolyte disturbance encountered in clinical practice, associated with significant morbidity and mortality. Chronic hyponatremia has negative effect on brain and bone tissue, and acute severe hyponatremia can have fatal outcome. Common cause of hyponatremia is the "syndrome of inappropriate antidiuretic hormone secretion" (SIADH), a condition characterized by dilutional hyponatremia due to unregulated secretion of antidiuretic hormone. SIADH can be idiopathic, but most often it is encountered in various clinical diseases. Although hyponatremia is a common electrolyte disturbance, its diagnosis is insufficient, SIADH is often unrecognized and hyponatremia is not appropriately treated. In this article we discuss the etiology of SIADH, diagnosis of hyponatremia and management of hyponatremia.