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http://hdl.handle.net/20.500.12188/29306
Title: | Outcome of patients with acute symptomatic pulmonary embolism and psychiatric disorders | Authors: | Diurbis Velasco, David Jiménez, Behnood Bikdeli, Alfonso Muriel, Pablo Javier Marchena, Inna Tzoran, Radovan Malý, Raquel López-Reyes, Antoni Riera-Mestre, Manuel Monreal, Bosevski, Marijan Zdraveska, Marija |
Keywords: | Depression Mortality Prognosis Pulmonary embolism |
Issue Date: | 2020 | Publisher: | Elsevier | Source: | Diurbis Velasco, David Jiménez, Behnood Bikdeli, Alfonso Muriel, Pablo Javier Marchena, Inna Tzoran, Radovan Malý, Raquel López-Reyes, Antoni Riera-Mestre, Manuel Monreal, Outcome of patients with acute symptomatic pulmonary embolism and psychiatric disorders, Thrombosis Research, Volume 193, 2020, Pages 90-97, ISSN 0049-3848, https://doi.org/10.1016/j.thromres.2020.05.052. | Journal: | Thrombosis Research | Abstract: | Objective: To address the association between psychiatric disorders and short-term outcomes after acute symptomatic pulmonary embolism (PE). Methods: We identified adults with PE enrolled in the RIETE registry between December 1, 2013, and January 31, 2019. Using multinomial regression, we assessed the association between a history of psychiatric disorders and the outcomes of all-cause mortality, PE-related mortality, and venous thromboembolism recurrence and bleeding rates through 30 days after initiation of treatment. We also examined the impact of depression on all-cause and PE-specific mortality. Results: Among 13,120 patients diagnosed with acute PE, 16.1% (2115) had psychiatric disorders and 4.2% died within the first 30-days of follow-up. Patients with psychiatric disorders had increased odds for all-cause (adjusted odds ratio [OR] 1.50; 95% CI, 1.21 to 1.86; P < 0.001) and PE-related mortality (adjusted OR 1.64; 95% CI, 1.09 to 2.48; P = 0.02) compared to those without psychiatric disorders. Multinomial logistic regression showed a non-significant trend toward lower risk of recurrences for patients with psychiatric disorders (adjusted OR 0.49; 95% CI, 0.21 to 1.15; P = 0.10). Psychiatric disorders were not significantly associated with increased odds for major bleeds during follow-up (adjusted OR 1.09; 95% CI, 0.85 to 1.40; P = 0.49). Results were consistent in a sensitivity analysis that only considered patients with a diagnosis of depression. Conclusions: In patients with acute PE, history of psychiatric disorders might predict all-cause and PE-related death in the ensuing month after diagnosis. | URI: | http://hdl.handle.net/20.500.12188/29306 | DOI: | 10.1016/j.thromres.2020.05.052 |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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