Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/29234
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dimzova, Marija | en_US |
dc.contributor.author | Kondova Topuzovska, Irena | en_US |
dc.contributor.author | Milenkovikj, Zvonko | en_US |
dc.contributor.author | Gaseva, Magdalena | en_US |
dc.contributor.author | Chaloska Ivanova, Viktorija | en_US |
dc.contributor.author | Serafimoski, Vladimir | en_US |
dc.contributor.author | Orovchanec, Nikola | en_US |
dc.date.accessioned | 2024-02-09T07:48:57Z | - |
dc.date.available | 2024-02-09T07:48:57Z | - |
dc.date.issued | 2018-07 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/29234 | - |
dc.description.abstract | The assessment of liver fibrosis in patients with chronic hepatitis B (CHB) is of great importance in evaluating the phases of chronic hepatitis B viral infection, prompt administration of antiviral therapy, prevention of disease progression and late complications of CHB infection. Aim: to investigate the clinical significance of quantitative HBs antigen as a predictor for liver fibrosis in patients with HBe antigen negative chronic hepatitis B and inactive carriers. Material and Methods: the study included 44 treatment naïve patients with chronic hepatitis B, divided into two groups, HBeAg negative chronic HBV infection or inactive carriers (IC) and HBeAg negative chronic hepatitis B patients. All patients underwent laboratory, serologic testing, ultrasound and transient elastography (TE). In both patient groups, quantitative HBs antigen (HBsQ), alanine aminotransferase (ALT), hepatitis B virus deoxyribonucleic acid (HBV DNA) and liver fibrosis were analyzed. Results: The value of HBsQ is significantly higher in patients with HBeAg negative CHB 2477.02±4535.44 IU/ml than in the IC group 8791±11891 IU/ml; Z=3.32, p<0.001 (p=0.0009). In IC patients, 1 (4.76%) had fibrosis and 20 (95.24%)) did not have fibrosis. Out of 23 patients with HBeAg negative chronic hepatitis B, 8 (34.78%) had fibrosis and 15 (65.22%) did not have fibrosis. Patients with HBeAg negative hepatitis B had significantly higher liver fibrosis than IC; Fisher Exact Test p<0.05 (p=0.02). The increase of HBsQ for one single unit (IU/ml) does not have predictive value for fibrosis (Ext (B) =1.00), 95% C.I. for EXP (B): 1.00-1.00 / p>0.05. Conclusion: Quantitative hepatitis B surface antigen has intermediate weak statistically insignificant prediction for liver fibrosis R=0.25 (p<0.10). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Macedonian Academy of Sciences and Arts | en_US |
dc.relation.ispartof | Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) | en_US |
dc.subject | chronic hepatitis B | en_US |
dc.subject | quantitative HBsAg | en_US |
dc.subject | HBe antigen | en_US |
dc.subject | HBV DNA | en_US |
dc.title | Clinical Significance of Quantitative HBs Antigen in the Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.2478/prilozi-2018-0023 | - |
dc.identifier.url | http://content.sciendo.com/view/journals/prilozi/39/1/article-p51.xml | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Dentistry | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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