Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/29214
DC Field | Value | Language |
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dc.contributor.author | Nikolova, Dafina | en_US |
dc.contributor.author | Chaloska ivanova, Viktorija | en_US |
dc.contributor.author | Jovanovikj, Rubens | en_US |
dc.contributor.author | Janevska, Vesna | en_US |
dc.contributor.author | Nikolovska Trpchevska, Emilija | en_US |
dc.contributor.author | Volkanovska, Anche | en_US |
dc.date.accessioned | 2024-02-08T10:21:14Z | - |
dc.date.available | 2024-02-08T10:21:14Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/29214 | - |
dc.description.abstract | Introduction: CD44, a transmembrane glycoprotein with a role in cell-cell and cell-matrix interactions and one of the stem cell markers, is considered to participate in progression and prognosis of hepatocellular carcinoma (HCC), which makes it a potential prognostic marker and therapeutic target. We aimed to evaluate immunoexpression of CD44 in tumor and surrounding non-tumor liver tissue and to correlate it to multiple clinicopathological data in order to determine its prognostic value in patients from the Republic of North Macedonia. Material and Methods: Presence of the immunosignal and the percentage of CD44+ tumor cells at the whole tumor tissue sample and adjacent cirrhotic liver tissue were semi-quantitatively determined. The immunohistochemistry results were correlated to B and C hepatitis, tumor dimensions, enlarged lymph nodes, T status, differentiation (G), microvascular invasion, and survival. Results: We found a significant difference in CD44 expression between tumor and non-tumor liver tissue (p < 0.000) and significantly higher CD44 expression was also found in T4 tumors in comparison with T1 tumors (p < 0.01). Conclusion: Expression of CD44 was significantly higher in tumor in comparison to non-tumor tissue and was significantly associated to T4 local tumor growth, making it a potential prognostic marker and therapeutic target. | en_US |
dc.publisher | Macedonian Association of Anatomists and Morphologists | en_US |
dc.relation.ispartof | JMS - Journal of Morphological Sciences | en_US |
dc.subject | CD44 | en_US |
dc.subject | HCC | en_US |
dc.subject | immunohistochemistry | en_US |
dc.subject | T status | en_US |
dc.subject | survival | en_US |
dc.title | Immunohistochemical expression of CD44 in patients with hepatocellular carcinoma | en_US |
dc.type | Article | en_US |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
Files in This Item:
File | Description | Size | Format | |
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IMMUNOHISTOCHEMICAL EXPRESSION OF CD44 IN PATIENTS WITH HEPATOCELLULAR CARCINOMA.pdf | 348.23 kB | Adobe PDF | View/Open |
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