Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/28203
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dc.contributor.authorSchnieder, Tatiana Pen_US
dc.contributor.authorZhou Qin, Isaiah Den_US
dc.contributor.authorTrencevska-Ivanovska, Iskraen_US
dc.contributor.authorRosoklija, Gorazden_US
dc.contributor.authorStankov, Aleksandaren_US
dc.contributor.authorPavlovski, Goranen_US
dc.contributor.authorMann, J Johnen_US
dc.contributor.authorDwork, Andrew Jen_US
dc.date.accessioned2023-10-16T13:16:42Z-
dc.date.available2023-10-16T13:16:42Z-
dc.date.issued2019-01-01-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/28203-
dc.description.abstractInflammatory processes may contribute to psychiatric disorders and suicide. Earlier, we reported greater densities of perivascular phagocytes in dorsal prefrontal white matter (DPFWM) in suicide than in non-suicide deaths. To distinguish between greater vascularity and greater coverage of vessels by perivascular phagocytes, and to determine whether the excess of perivascular phagocytes is derived from microglia or from non-parenchymal immune cells, we made stereological estimates of vascular surface area density (AVTOTAL) by staining for glucose transporter Glut-1, and the fraction of vascular surface area (AF) immunoreactive (IR) for CD163 (CD163 AF) in dorsal and ventral prefrontal white and gray matter. Manner of death or psychiatric diagnosis showed no association with CD163 AF in any region. Suicide was associated with a lower AVTOTAL compared with non-suicides in DPFWM (p = 0.018) but not with AVTOTAL in the 3 other regions of interest. Thus, the earlier observation of increased density of perivascular phagocytes in DPFWM after suicide cannot be attributed to infiltration by peripheral monocytes or to increased vascularity. Greater AVTOTAL ventrally than dorsally (p = 0.002) was unique to suicide and white matter.en_US
dc.language.isoenen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.ispartofJournal of Neuropathology & Experimental Neurologyen_US
dc.subjectBlood-brain barrieren_US
dc.subjectCD163en_US
dc.subjectCerebrovasculatureen_US
dc.subjectGlut-1en_US
dc.subjectInflammationen_US
dc.subjectMonocytesen_US
dc.subjectUnbiased stereologyen_US
dc.titleBlood Vessels and Perivascular Phagocytes of Prefrontal White and Gray Matter in Suicideen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/jnen/nly103-
dc.identifier.urlhttp://academic.oup.com/jnen/article-pdf/78/1/15/27089026/nly103.pdf-
dc.identifier.volume78-
dc.identifier.issue1-
dc.identifier.fpage15-
dc.identifier.lpage30-
item.grantfulltextnone-
item.fulltextNo Fulltext-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
Appears in Collections:Faculty of Medicine: Journal Articles
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