Cognitive disorders in patients with chronic kidney disease: specificities of clinical assessment

Pépin, Marion; Ferreira, Ana Carina; Arici, Mustafa; Bachman, Maie; Barbieri, Michelangela; Bumblyte, Inga Arune; Carriazo, Sol; Delgado, Pilar; Garneata, Liliana; Giannakou, Konstantinos; Godefroy, Olivier; Grodzicki, Tomasz; Klimkowicz-Mrowiec, Aleksandra; Kurganaite, Justina; Liabeuf, Sophie; Mocanu, Carmen Antonia; Paolisso, Giuseppe; Spasovski, Goce; Vazelov, Evgueniy Stefanov; Viggiano, Davide

doi:10.1093/ndt/gfab262

Cognitive disorders in patients with chronic kidney disease: specificities of clinical assessment

Journal

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Date Issued

2021-12-28

Author(s)

Pépin, Marion

Ferreira, Ana Carina

Arici, Mustafa

Bachman, Maie

Barbieri, Michelangela

Bumblyte, Inga Arune

Carriazo, Sol

Delgado, Pilar

Garneata, Liliana

Giannakou, Konstantinos

Godefroy, Olivier

Grodzicki, Tomasz

Klimkowicz-Mrowiec, Aleksandra

Kurganaite, Justina

Liabeuf, Sophie

Mocanu, Carmen Antonia

Paolisso, Giuseppe

Vazelov, Evgueniy Stefanov

Viggiano, Davide

Zoccali, Carmine

Massy, Ziad A

Więcek, Andrzej

DOI

10.1093/ndt/gfab262

Abstract

Neurocognitive disorders are frequent among chronic kidney disease (CKD) patients. Identifying and characterizing cognitive impairment (CI) can help to assess the ability of adherence to CKD risk reduction strategy, identify potentially reversible causes of cognitive decline, modify pharmacotherapy, educate the patient and caregiver and provide appropriate patient and caregiver support. Numerous factors are associated with the development and progression of CI in CKD patients and various conditions can influence the results of cognitive assessment in these patients. Here we review clinical warning signs that should lead to cognitive screening; conditions frequent in CKD at risk to interfere with cognitive testing or performance, including specificities of cognitive assessment in dialysis patients or after kidney transplantation; and available tests for screening and observed cognitive patterns in CKD patients.