Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/26101
DC Field | Value | Language |
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dc.contributor.author | Petrushevska, Marija | en_US |
dc.contributor.author | Zendelovska, Dragica | en_US |
dc.contributor.author | Atanasovska, Emilija | en_US |
dc.contributor.author | Spasovska, Katerina | en_US |
dc.contributor.author | Grozdanovski, Krsto | en_US |
dc.contributor.author | Stojanovska, Simona | en_US |
dc.contributor.author | Panovska Stavridis, Irina | en_US |
dc.contributor.author | Eftimov, Aleksandar | en_US |
dc.date.accessioned | 2023-03-15T09:35:43Z | - |
dc.date.available | 2023-03-15T09:35:43Z | - |
dc.date.issued | 2023-01-12 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/26101 | - |
dc.description.abstract | <jats:p>Our objective was to investigate the inflammatory and oxidative stress markers in patients with moderate and severe form of COVID-19. In addition, we show the correlation between changes in lymphocyte subsets and markers of oxidative stress as a tool for patient classification. IL-6 and VEGF were analysed by utilizing a High Sensitivity Evidence Investigatorâ„¢ Biochip Array technology. The total antioxidant capacity (PAT) and the free radical concentrations (d-ROM) were measured in serum utilizing analytical photometric system FRAS5. Peripheral blood was used to determine CD45 + mononuclear, B, T, and NK cells using a multi-parameter flow cytometric immunophenotypic test. Statistically significant differences in IL-6 and VEGF levels were observed between the two patient groups. Decreased values of the absolute number of lymphocytes and their CD4 + and CD8 + positive T cells, NK cells, and CD8 were obtained. In the moderate group, good correlations were found between IL-6 and VEGF and NK cells (r = 0.6973, p <0.05; for IL6 and r = 0.6498, p <0, for VEGF. 05). Cytokines were correlated with CD45+ (r = 0.5610, p <0.05; for IL-6 and r = 0.5462, p <0.05 for VEGF). The oxidative stress index can be used as a cheaper alternative and as a triage tool between severe and moderate illnesses, after showing good correlation with more expensive patient classification analysis.</jats:p> | en_US |
dc.language.iso | en | en_US |
dc.publisher | PAGEPress Publications | en_US |
dc.relation.ispartof | Italian Journal of Medicine | en_US |
dc.title | Interplay between lymphocyte subpopulation, inflammatory cytokines and their correlation with oxidative stress parameters in COVID-19 | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.4081/itjm.2022.1543 | - |
dc.identifier.url | https://www.italjmed.org/index.php/ijm/article/download/1543/1437 | - |
dc.identifier.url | https://www.italjmed.org/index.php/ijm/article/download/1543/1437 | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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