Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/24570
DC Field | Value | Language |
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dc.contributor.author | Boshkovska, Katerina | en_US |
dc.contributor.author | Naceva Fustic, Stojka | en_US |
dc.contributor.author | Simonovska, Liljana | en_US |
dc.contributor.author | Dilberovska, Mirjana | en_US |
dc.contributor.author | Dacevski, Dragan | en_US |
dc.contributor.author | Popova, Gorica | en_US |
dc.contributor.author | Arnaudova, Ivana | en_US |
dc.contributor.author | Cakalarovska, Irena | en_US |
dc.date.accessioned | 2022-11-25T12:28:58Z | - |
dc.date.available | 2022-11-25T12:28:58Z | - |
dc.date.issued | 2018-11-25 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/24570 | - |
dc.description.abstract | AIM: This study aimed to evaluate the importance of IFN-γ in the diagnosis of pediatric TB and LTBI and to compare the IFN-γ levels. METHODS: We analysed 100 patients examined for possible M. tuberculosis infection or disease at the Institute of Respiratory Diseases in Children, Kozle, Skopje. Patients were divided into 2 groups: TB disease and LTBI. The following parameters were analyzed: demographic characteristics, history of previous exposure to active TB, BCG vaccination and presence of BCG scar, lung X-ray findings, tuberculin skin test by the Monteux method and the value of INF-γ according to the Quantiferon TB gold test, direct samples of acid-alcohol-resistant bacilli of sputum and Löwenstein Jensen cultures. Informed parental consent was obtained for each child included in the study. RESULTS: In the LTBI group 60.9% had a scar from the vaccination while in the TB group 50% had BCG scar. TST induration diameters in children with or without BCG scar were significantly larger in patients with active TB. Children with active TB had significantly higher IFN-γ levels than children with LTBI. The IFN-γ for the cut-off of 0.35 IU/ml, has 64% sensitivity for detection of LTBI, versus 80.6% sensitivity for active disease. Children with close TB contact had significantly higher IFN-γ levels. Correlation between TST induration diameter and IFN-γ levels was stronger in the TB group. CONCLUSION: IFN-γ levels are significantly higher in children with active TB, and children with close contact with TB patient. It has better sensitivity in active TB. Using both tests (IFN-γ and TST) can improve the diagnose of LTBI and TB in countries where vaccination with BCG is widespread. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ID Design Press,Skopje, Republic of Macedonia | en_US |
dc.relation.ispartof | Open Access Macedonian Journal of Medical Sciences | en_US |
dc.subject | children | en_US |
dc.subject | latent tuberculosis infection | en_US |
dc.subject | tuberculosis | en_US |
dc.subject | tuberculin skin test | en_US |
dc.subject | IFN-γ | en_US |
dc.title | Comparison od IFN-γ levels in children with tuberculosis desease(TB) and latent tuberculosis infection (LTBI). | en_US |
dc.type | Article | en_US |
dc.identifier.eissn | 1857-9655 | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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File | Description | Size | Format | |
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Katerina Boskovska OA MJMS.pdf | 657.84 kB | Adobe PDF | View/Open |
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