Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/23771
Title: Immune thrombocytopenic purpura in adults in the last 10 years: single-centre experience
Authors: Pavkovic M 
Trpkovska-Terzieva S
Sotirova T 
Latifi A
Cevreska L 
Stojanovic A
Issue Date: 2012
Publisher: Македонска академија на науките и уметностите, Одделение за биолошки и медицински науки = Macedonian Academy of Sciences and Arts, Section of Biological and Medical Sciences
Journal: Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za bioloski i medicinski nauki)
Abstract: Abstract Background: Immune thrombocytopenic purpura (ITP) is a benign disease with low morbidity and mortality and frequent remissions that occur spontaneously or in response to first-line treatment with steroids or splenectomy. Aim: The purpose of this study is to describe the clinical outcomes of 170 patients with ITP diagnosed and/or treated in our hospital between 2000 and 2010. Methods and results: The median age at diagnosis was 47 years. Forty three (25%) were asymptomatic, 65% had minor skin or mucosal bleeding and 10% had significant bleeding from the gastrointestinal or genitourinary system. The median platelet count at diagnosis was 13x10(9)/L (range: 0-98x10(9)/L). Median follow-up of all patients was 13 months. Ninety-five patients had a follow-up longer than 12 months, with median 44 months (range 14-384). Corticosteroids were the initial treatment for 161/170 (95%) patients, 38 (22%) were splenectomized, 25 (14.7%) were treated with intravenous gamma globulins, while 9 did not received any specific treatment. A complete response to initial treatment (prednisone±splenectomy) was achieved in 55/161 (34.2%), a partial response in 90 (55.9%) and no response in 16 (9.9%) patients. In the group of patients with follow-up longer than 1 year; 28 (29%) patients had refractory or unresponsive ITP with a median follow-up of 66 months. All patients with refractory ITP were treated with steroids, 11 were splenctomized, significantly more patients with refractory ITP 12 (43%) were treated with IVIG compared with other ITP patients (16%), p=0.005. The median age of 38 splenectomized patients was 28 years and it is significantly different from the other patients (p<0.001). There were no significant differences in other characteristics between splenctomized or refractory ITP and other patients at diagnosis. Conclusion: Our results were similar to results already reported in other similar studies.
URI: http://hdl.handle.net/20.500.12188/23771
Appears in Collections:Faculty of Medicine: Journal Articles

Files in This Item:
File Description SizeFormat 
IMMUNE THROMBOCYTOPENIC PURPURA IN ADULTS Prilozi.pdf174.88 kBAdobe PDFView/Open
Show full item record

Page view(s)

40
checked on May 2, 2025

Download(s)

13
checked on May 2, 2025

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.