VASCULAR COMPLICATIONS IN PATIENTS WITH DIABETES MELLITUS TYPE 2 AND CORRELATION WITH ELEVATED HOMOCYSTEINE LEVELS AS A RISK FACTOR
Journal
International journal of advanced medicine
Date Issued
2020-01
Author(s)
Bogoeva Kostovska, Ksenija
Abstract
Background Elevated homocysteine levels (tHcy), oxidative stress and prolonged hyperglycemia are considered as
potential factors for vascular endothelial damage. Correlation between elevated plasma homocysteine and
microvascular or macrovascular complications of diabetes mellitus patients, and its possible role as an early predictor for endothelial
imparement, is a scientific challenge up to date.Methods
diabetes mellitus type 2 more than 12 months, glycosylated haemoglobin HbA1c ≥ 7,5%, BMI ≤ 40 kg/m2 and prescribed oral antidiabetic
drugs (OAD) and / or insulin therapy, divided into two groups: 50 patients diagnosed with vascular complications and 30 patients without
vascular complications. Complete haemogram, glycemic profile. HbA1c, lipid prorenal function tests, plasma tHcy levels, ultrasound,
doppler sonography, blood preasure measurements, oftalmoscopy and urine test for microalbuminuria were performed in each patient.
ResultsElevated levels of homocysteine within 16,05 ± 0,83 μmol/l were detected in the group of diabetic subjects with microvascular and
macrovascular complications compared to the group where no complications were diagnosed and levels of homocysteine were 10,44 ± 0,24
μmol/l. Elevated homocisteine levels represent an additional risk factor for endothelial imparement in patients with diabetes Conclusion
mellitus type 2. However, further research would provide clear evidence of the impact on endothelial vascular damage and long-term vascular
complications
potential factors for vascular endothelial damage. Correlation between elevated plasma homocysteine and
microvascular or macrovascular complications of diabetes mellitus patients, and its possible role as an early predictor for endothelial
imparement, is a scientific challenge up to date.Methods
diabetes mellitus type 2 more than 12 months, glycosylated haemoglobin HbA1c ≥ 7,5%, BMI ≤ 40 kg/m2 and prescribed oral antidiabetic
drugs (OAD) and / or insulin therapy, divided into two groups: 50 patients diagnosed with vascular complications and 30 patients without
vascular complications. Complete haemogram, glycemic profile. HbA1c, lipid prorenal function tests, plasma tHcy levels, ultrasound,
doppler sonography, blood preasure measurements, oftalmoscopy and urine test for microalbuminuria were performed in each patient.
ResultsElevated levels of homocysteine within 16,05 ± 0,83 μmol/l were detected in the group of diabetic subjects with microvascular and
macrovascular complications compared to the group where no complications were diagnosed and levels of homocysteine were 10,44 ± 0,24
μmol/l. Elevated homocisteine levels represent an additional risk factor for endothelial imparement in patients with diabetes Conclusion
mellitus type 2. However, further research would provide clear evidence of the impact on endothelial vascular damage and long-term vascular
complications