Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/23383
DC Field | Value | Language |
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dc.contributor.author | Krstevska balkanov, Svetlana | en_US |
dc.contributor.author | Trajkova, Sanja | en_US |
dc.contributor.author | Pivkova Veljanovska, Aleksandra | en_US |
dc.contributor.author | Panovska Stavridis, Irina | en_US |
dc.contributor.author | Genadieva Stavrikj, Sonja | en_US |
dc.contributor.author | Popova-Labachevska, Marija | en_US |
dc.contributor.author | Spasovski, Dejan | en_US |
dc.contributor.author | Rambabova Bushljetic, Irena | en_US |
dc.contributor.author | Kalchev, Goce | en_US |
dc.date.accessioned | 2022-10-12T09:14:19Z | - |
dc.date.available | 2022-10-12T09:14:19Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.citation | Svetlana Krstevska Balkanov, Sanja Trajkova , Sonja Genadieva Stavric , Aleksandra Pivkova Veljanovska, Marija Popova Labacevska , Dejan Spasovski , Irena Rambabova Bushljetik , Goce Kalcev, Irina Panovska Stavridis. Myeloma multiplex treatment and overall survival. Mac. Pharm. Bull. Vol. 67(1) 2021 | en_US |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/23383 | - |
dc.description.abstract | The Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. This retrospective-prospective study was conducted at the University Clinic for Hematology in Skopje, North Macedonia, in the period between January 2009 and December 2019. Patients younger than 65 years, without comorbidities, fit for autologous peripheral blood stem cell transplantation (PBSCT), were treated with Cyclophosphamide-Thalidomide-Dexamethasone (CyThalDex) protocol divided into two daily doses which were maintained until complete remission. Patients over 65 years of age, unfit for more aggressive treatment options like peripheral blood stem cells (PBSCT) with comorbidities and renal failure, were treated with MelphalanPrednisone-Thalidomide (MPT) protocol. The third group of patients was treated without new immunomodulators such as thalidomide, but instead a salvage therapy was given consisted of chemotherapy and corticosteroids. The use of thalidomide can lead to more undesirable effects such as deep vein thrombosis and renal neuropathy. The results obtained in our study showed no high percentage of these effects. However, a better survival rate was registered along with a longer period without progression of the underlying disease (PFS). Moreover, a higher percentage of complete remission (CR) was achieved and a very good partial response (VGPR) in general. Myeloma multiplex is still incurable disease with pattern of regression and remission followed by multiple relapses rising from the residual myeloma cells, but in the future still many unsolved questions has to be answered | en_US |
dc.language.iso | en | en_US |
dc.publisher | Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy | en_US |
dc.relation.ispartof | Macedonian pharmaceutical bulletin | en_US |
dc.subject | myeloma multiplex | en_US |
dc.subject | autologous stem cell transplantation | en_US |
dc.subject | Thalidomide | en_US |
dc.title | Myeloma multiplex treatment and overall survival | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.33320/maced.pharm.bull.2021.67.01.008 | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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File | Description | Size | Format | |
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mm survival.pdf | 722.14 kB | Adobe PDF | View/Open |
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