F-18 FDG-PET/CT imaging in recurrent and metastatic colorectal carcinoma: metabolic characteristics
Date Issued
2020
Author(s)
Beshliev, Simon
Angeleska, Meri
Abstract
Objectives:
The purpose of this study was to evaluate the metabolic characteristics of recurrent colorectal carcinoma at the surgery site
and distant metastases after treatment.
Material and Methods:
Records of 78 patients with colorectal carcinoma 50 men, 28 women, mean age: 60 years, (range: 28-82 years) who were
treated and uderwent FDG PET/CT scanning for restaging of colorectal carcinoma. Increased FDG uptake in the postsurgical
area, liver parenchyma and lung nodules >9mm were retrospectively analysed and SUVmax as well tumor to liver ratio
(TLR) were calculated.
Results:
In 20 patients (25%) there was increased FDG uptake in the liver parenchyma with SUVmax=8.07 (range: 4.1-17) and
TLR=3.0 (range: 1.7-6.5). Increased FDG uptake in the postsurgical area suspicious for local recurrence was detected in 14
patients (18%) with SUVmax=9.85 (range: 3,6- 24.7) and TLR=3.9 (range: 1.1-9.5). Lung nodules with average diameter
of 15.4mm (range: 10- 27mm) were detected in 18 patients (23%) with SUVmax=5.0 (range:1.5-10) and mean TLR=1.8
(range: 0.5-3.4)
Conclusion:
The widely used semiquantitive measurements SUVmax and TLR significantly vary in local recurrence and distant metastasis
in colorectal cancer. FDG uptake was highest in local recurrence, and lower in distant metastases. The lung metastases
showed lower metabolic activity compared to liver metastases. These features should be taken into account during the interpretation
of the scans in these patients.
The purpose of this study was to evaluate the metabolic characteristics of recurrent colorectal carcinoma at the surgery site
and distant metastases after treatment.
Material and Methods:
Records of 78 patients with colorectal carcinoma 50 men, 28 women, mean age: 60 years, (range: 28-82 years) who were
treated and uderwent FDG PET/CT scanning for restaging of colorectal carcinoma. Increased FDG uptake in the postsurgical
area, liver parenchyma and lung nodules >9mm were retrospectively analysed and SUVmax as well tumor to liver ratio
(TLR) were calculated.
Results:
In 20 patients (25%) there was increased FDG uptake in the liver parenchyma with SUVmax=8.07 (range: 4.1-17) and
TLR=3.0 (range: 1.7-6.5). Increased FDG uptake in the postsurgical area suspicious for local recurrence was detected in 14
patients (18%) with SUVmax=9.85 (range: 3,6- 24.7) and TLR=3.9 (range: 1.1-9.5). Lung nodules with average diameter
of 15.4mm (range: 10- 27mm) were detected in 18 patients (23%) with SUVmax=5.0 (range:1.5-10) and mean TLR=1.8
(range: 0.5-3.4)
Conclusion:
The widely used semiquantitive measurements SUVmax and TLR significantly vary in local recurrence and distant metastasis
in colorectal cancer. FDG uptake was highest in local recurrence, and lower in distant metastases. The lung metastases
showed lower metabolic activity compared to liver metastases. These features should be taken into account during the interpretation
of the scans in these patients.
Subjects
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