Solitary lung metastasis of malignant melanoma - Case report
Date Issued
2017-04
Author(s)
Kochovska Kamchevska Nade
Bushev Jane
Smileska Snezana
Baloski Marjan
Sajkovska Iva
Poposki Bozidar
Trajkovska Vanche
Abstract
Malignant melanoma is increasing last thirty years, one of the most common cancers in young adults (especially
women). Primary localization on skin, mouth, intestines, eye. Survival in malignant melanoma stage IV is 10-15%,
better prognosis have patients with normal lactate dehydrogenase (LDH). Lung metastases are usually asymptomatic, multiple, nodular. Desmoplastic (neurotropic, spindle cell) melanoma is rare form of infiltrating carcinoma, with
diificult diagnosis due to similarity to un-melanocytic lesion as scar, fibroma, cyst.
Female patient, 69 years of age, hospitalized for changes seen on chest X-ray. Symptoms: intermittent pain in left
shoulder, dyspnea. Profession: housewife, non-smoker, comorbidity: arterial hypertension. Normal lung auscultatory
finding. Laboratory: sedimentation 20, hemoglobin 11,9, LDH and tumor markers (CA19-9, CEA, CA 125, CA 15-3) normal. Chest X-ray: left apical, oval, soft-tissue shadowing. Bronchoscopy – without pathological findings. A computed
tomographic chest scan showed: in left apicoposterior segment, solid formation with dimensions 18x13,6mm, close
to the pleura, that accumulated contrast, two mediastinal lymph nodes 5,7mm and 8,5mm. CT guided transthoracic
lung core biopsy was performed. Histopathological diagnosis - Metastatic process of Spindle cell melanoma malignum. Microscopic examination with accumulation of large, pleomorphic cells with deposits of melanin irregularly
arranged. The origin and systemic dissemination of the melanoma was investigated. Abdominal ultrasound without
abnormalities. Dermatological, ophthalomological, gastroenterohepatological examinationas were performed, but
the primary lesion remained unknown. The patient denied to receive proposed oncological and surgical therapy.
Two years after, control CT scan, the tumor was 47x43mm, in right lung secondary deposite 11x8mm, increased mediastinal lymph nodes to 18mm.
women). Primary localization on skin, mouth, intestines, eye. Survival in malignant melanoma stage IV is 10-15%,
better prognosis have patients with normal lactate dehydrogenase (LDH). Lung metastases are usually asymptomatic, multiple, nodular. Desmoplastic (neurotropic, spindle cell) melanoma is rare form of infiltrating carcinoma, with
diificult diagnosis due to similarity to un-melanocytic lesion as scar, fibroma, cyst.
Female patient, 69 years of age, hospitalized for changes seen on chest X-ray. Symptoms: intermittent pain in left
shoulder, dyspnea. Profession: housewife, non-smoker, comorbidity: arterial hypertension. Normal lung auscultatory
finding. Laboratory: sedimentation 20, hemoglobin 11,9, LDH and tumor markers (CA19-9, CEA, CA 125, CA 15-3) normal. Chest X-ray: left apical, oval, soft-tissue shadowing. Bronchoscopy – without pathological findings. A computed
tomographic chest scan showed: in left apicoposterior segment, solid formation with dimensions 18x13,6mm, close
to the pleura, that accumulated contrast, two mediastinal lymph nodes 5,7mm and 8,5mm. CT guided transthoracic
lung core biopsy was performed. Histopathological diagnosis - Metastatic process of Spindle cell melanoma malignum. Microscopic examination with accumulation of large, pleomorphic cells with deposits of melanin irregularly
arranged. The origin and systemic dissemination of the melanoma was investigated. Abdominal ultrasound without
abnormalities. Dermatological, ophthalomological, gastroenterohepatological examinationas were performed, but
the primary lesion remained unknown. The patient denied to receive proposed oncological and surgical therapy.
Two years after, control CT scan, the tumor was 47x43mm, in right lung secondary deposite 11x8mm, increased mediastinal lymph nodes to 18mm.
Subjects
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