Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/1763
Title: Methylenetetrahydrofolate reductase (MTHFR-677 and MTHFR-1298) genotypes and haplotypes and plasma homocysteine levels in patients with occlusive artery disease and deep venous thrombosis
Authors: Spiroski, Igor 
Kedev, Sashko 
Antov, Slobodan
Arsov, Todor
Krstevska, Marija 
Dzhekova-Stojkova, Sloboda
Bosilkova, Gordana 
Kostovska, Stojanka
Trajkov, Dejan 
Petlichkovski, Aleksandar 
Strezova, Ana
Efinska-Mladenovska, Olivija
Spiroski, Mirko
Issue Date: 2008
Journal: Acta biochimica Polonica
Abstract: The aim was to investigate different genotypes and haplotypes of methylenetetrahydrofolate reductase (MTHFR-677, -1298) and plasma concentration of total homocysteine (tHcy) in Macedonian patients with occlusive artery disease (OAD) and deep venous thrombosis (DVT). Investigated groups consists of 80 healthy, 74 patients with OAD, and 63 patients with DVT. Plasma tHcy was measured with Microplate Enzyme Immunoassay. Identification of MTHFR genotypes and haplotypes was done with CVD StripAssay. The probability level (P-value) was evaluated by the Student's t-test. Plasma concentration of tHcy in CC and CT genotypes of MTHFR C677T was significantly increased in patients with OAD and in patients with DVT. Plasma concentration of tHcy in AC genotype of MTHFR A1298C was increased in patients with OAD and in patients with DVT. Plasma concentration of tHcy was significantly increased in AA genotype of patients with OAD, but not in patients with DVT. We found a significant increase of plasma tHcy in patients with OAD in comparison with healthy respondents for normal:heterozygote (CC:AC), heterozygote:normal (CT:AA), and heterozygote:heterozygote (CT:AC) haplotypes. Plasma concentration of tHcy in patients with DVT in comparison with healthy respondents was significantly increased for normal:normal (CC:AA), normal heterozygote (CC:AC), and heterozygote:heterozygote (CT:AC) haplotypes. We conclude that MTHFR C677T and MTHFR A1289C genotypes and haplotypes are connected with tHcy plasma levels in Macedonian patients with OAD and DVT.
URI: http://hdl.handle.net/20.500.12188/1763
ISSN: 0001-527X
Appears in Collections:Faculty of Medicine: Journal Articles

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