Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/17356
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dc.contributor.authorAna Kocevskaen_US
dc.contributor.authorBiljana Jovanoska Todorovaen_US
dc.contributor.authorKristina Skeparovskaen_US
dc.contributor.authorBashkim Ismailien_US
dc.contributor.authorPranvera Izairien_US
dc.contributor.authorSHpishikj Pushevska, Anamarijaen_US
dc.contributor.authorMarina Karovskaen_US
dc.date.accessioned2022-04-11T07:34:46Z-
dc.date.available2022-04-11T07:34:46Z-
dc.date.issued2022-03-24-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/17356-
dc.description.abstractObjectives: To determine the histopathological changes of the endometrium that occur during the period of perimenopause and postmenopause and to determine their association with the presence of obesity and the levels of bone markers for bone resorpition and bone formation, serum parathormone, vitamin D and calcium levels. Material and methods: This study involved 120 patients with fractionated explorative curettage due to abnormal uterine bleeding. The examined group was divided in two subgroups: 60 women in perimenopausis and 60 women in postmenopausis. Anamnestic data were taken from from all respondents. Body height and weight were measured. This laboratory analyses were performed: Serum Osteocalcin, beta CTX, parathormone, Vitamin D and calcium levels. Results: The most common pathological change of the endometrium was an endometrial polyp. History of previous bone fractures was significantly more common in postmenopausal women than in perimenopausal women. Postmenopausal women were older than perimenopausal and had significantly higher Body Mass Index, higher levels of serum osteocalcin and beta CTX in serum. Postmenopausal duration significantly positively correlated with Osteocalcin and β Cross Laps serum values. Higher serum Osteocalcin and β Cross Laps values were measured in patients with longer postmenopause duration. There was not significant difference in the levels of vitamin D and calcium between the groups. Conclusions: In the period of perimenopause and postmenopause, there are changes in the genital organs, but also there are internal disorders (obesity, metabolic syndrome, diabetes, thyroid disorders, cardiovascular disease, osteoporosis), which should be timely prevented, diagnosed and treated. Estrogen deficiency in postmenopausis is the most common cause of postmenopausal osteoporosis.en_US
dc.language.isoenen_US
dc.publisherInternational Osteoporosis Foundationen_US
dc.subjectendometriumen_US
dc.subjectperimenopauseen_US
dc.subjectpostmenopauseen_US
dc.subjectOsteocalcinen_US
dc.subjectβ Cross Lapsen_US
dc.subjectosteoporosisen_US
dc.titleBONE MARKERS IN PERIMENOPAUSAL AND POSTMENOPAUSAL WOMEN WITH ABNORMAL UTERINE BLEEDINGen_US
dc.typeProceeding articleen_US
dc.relation.conferenceWORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSCELETAL DISEASESen_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
Appears in Collections:Faculty of Medicine: Conference papers
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