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Title: Characteristics of an Outpatient Cohort with HBeAg-Negative Chronic Hepatitis B
Authors: Dimzova, Marija 
Bosilkovski, Mile 
Kondova Topuzovska, Irena 
Gaseva, Magdalena
Toshevki, Boban
Petreska, B
Jakimovski, Dejan 
Keywords: ALT
Chronic hepatitis B
Inactive carriers
Quantitative HBsAg
Issue Date: 14-Jul-2019
Publisher: Scientific foundation Spiroski
Source: Dimzova M, Bosilkovski M, Kondova-Topuzovska I, Gaseva M, Toshevki B, Petreska B, Jakimovski D. Characteristics of an Outpatient Cohort with HBeAg-Negative Chronic Hepatitis B. Open Access Maced J Med Sci. 2019 Jul 14;7(13):2068-2074. doi: 10.3889/oamjms.2019.623. PMID: 31456827; PMCID: PMC6698117.
Journal: Open Access Macedonian Journal of Medical Sciences 
Abstract: Background: Patients with hepatitis Be antigen-negative chronic hepatitis B (HBeAg-negative CHB), and patients' inactive carriers (IC) have similar laboratory and serologic characteristics and are not always easy to distinguish. Aim: To characterise hepatitis Be antigen (HBeAg) negative chronic hepatitis B cohort based on their laboratory and virology evaluations at one point of time. Methods: A prospective non-randomized study was conducted on 109 patients with HBeAg negative chronic hepatitis B treated as outpatients at the Clinic for Infectious Diseases and Febrile Conditions. All patients underwent laboratory and serology testing, quantification of HBV DNA and HBs antigen (qHBsAg). Results: A group of 56 patients were inactive carriers (IC), and 53 patients had HBeAg-negative CHB (AH). The mean values of ALT, HBV DNA and qHBsAg in IC were 29.13 U/L; 727.95 IU/ml and 2753.73 IU/ml respectively. In the AH group, the mean values of ALT, HBV DNA and quantitative HBsAg were 50.45 U/L; 7237363.98 IU/ml and 12556.06 IU/ml respectively. The serum value of ALT was more influenced by qHBsAg than HBV DNA in both IC and AH groups (R = 0.22 vs R = 0.15) (p > 0.05). Conclusion: patients with inactive and active HBeAg-negative CHB have similar laboratory and serology profile. It is necessary to combine analysis of ALT, HBV DNA and qHBsAg for better discrimination between patient's IC and patient with HBeAg-negative CHB. Keywords: ALT; Chronic hepatitis B; HBV DNA; HBeAg; Inactive carriers; Quantitative HBsAg.
DOI: 10.3889/oamjms.2019.623
Appears in Collections:Faculty of Medicine: Journal Articles

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