BODY FAT DISTRIBUTION CHANGES DURING WIGHT LOSS DETERMINED BY DXA ANDROID/GYNOID INDEXES OF ABDOMINAL OBESITY

Abstract

The effect of weight loss on body fat distribution was examined through central obesity indexes (COI), which are android/gynoid tissue and fat mass ratios determined by dual-energy X-ray absorptiometry (DXA) and their relationship with lipid profile changes. The following parameters were determined before and after weight loss in 4 postmenopausal women: body mass index (BMI), body weight (BW), android (A) and gynoid (G) tissue mass (TM) and fat mass (FM) and their % with DXA, and their ratios as indexes of abdominal fat distribution COI1 (A/G-TM), COI2 (A/G-FM), COI3 (A/G-TMfat%) and COI4 (A/G-FM%), as well as lipid profile: total cholesterol (C), triglycerides (TG), HDL-C, LDL-C, LDL/HDL-C, C/HDL-C and TG/HDL-C. BW of 63±1.4 kg and BMI value of 29±0.65 kg/m2 lowered after the weight loss to 49±1.6 kg and normal BMI 22.62±0.74 kg/m2 (p<0.012). COI1 value decreased significantly from 0.5±0.01 to normal value 0.42±0.02 (p<0.003). COI2 value decreased significantly from 0.45±0.02 to normal value 0.34±0,02 (p<0.0004). COI3 value decrease from 0.95±0.026 to 0.74±0.012 was significant (p<0.0009) and COI4 value decrease from 0.95±0.01 to 0.74±0.02 was also significant (p<0.0001). Atherogenic indexes TG/HDL-C, LDL/HDL-C and C/HDL lowered significantly after the weight loss (p<0.002; p<0.03 and p<0.05) as well as TG, C and LDL values (p<0.001; p<0.01; p<0.01). It was confirmed that DXA indexes of central, abdominal obesity COI1 and COI2 were increased in overweight women before the weight loss and lowered significantly after the weight loss to normal values, indicating that normal BMI and BW reached after the weight loss were associated with normalized body fat distribution, and significant reduction of the atherogenic lipid profile indicating reduced atherogenic risk.