Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/1666
DC FieldValueLanguage
dc.contributor.authorMeri Kirijasen_US
dc.contributor.authorSonja Genadieva Stavriken_US
dc.contributor.authorDejan Trajkoven_US
dc.contributor.authorSlavica Hristomanova Mitkovskaen_US
dc.contributor.authorAleksandar Seneven_US
dc.contributor.authorOlivija Efinska Mladenovskaen_US
dc.contributor.authorOlgica Sibinovskaen_US
dc.contributor.authorAleksandar Petlichkovskien_US
dc.date.accessioned2019-03-12T10:36:31Z-
dc.date.available2019-03-12T10:36:31Z-
dc.date.issued2018-12-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/1666-
dc.description.abstractThe importance of HLA alleles in the process of haematopoietic stem cell transplantation, especially the process of unrelated donor search, is enormous. Macedonian Bone Marrow Donor Registry was established in 2010 and has registered volunteer donors from different nationalities that live in the Republic of Macedonia. The aim of this study was to determine the HLA allele and haplotype frequencies of the volunteer donors from the Macedonian Bone Marrow Donor Registry and to compare this results with the Macedonians from a family study. We analyzed 1,541 donors, with different nationalities, Macedonian, Albanian and Macedonian Muslims that were most numerous in MBMDR, and typed them for HLA-A, -B, -C, -DRB1, whereas Macedonian also for HLA-DQA1 and HLA-DQB1 by SSO method (One Lambda, CA, USA). The most frequent alleles in Macedonians were HLA-A*02, 01, 24; HLA-B*35, 18, 51; HLA-C*07, 04, 12; HLA-DRB1*11, 16, 13; HLA-DQA1*01, 05 and HLA-DQB1*05, 03, 06; in Albanians they were HLA-A*02, 24,01; HLA-B*51, 18, 35; HLA-C*07, 04, 12, HLA-DRB1*11, 13,16; and in Macedonian Muslims they were HLA-A*02, 01, 24; HLA-B*18, 51, 35, HLA-C*07, 04, 02 and HLA-DRB1*11, 16, 14. The most common haplotype in Macedonian was HLA-A*01-B*08-C*07-DRB1*03, whilst in Albanian and Macedonian Muslims HLA-A*02-B*18-C*07-DRB1*11. The comparison of the HLA allele groups between Macedonian from MBMDR and family study showed similar distribution. This study confirmed the close relationship between the populations that live in the Balkan Peninsula.en_US
dc.language.isoenen_US
dc.publisherWiley Online Libraryen_US
dc.relation.ispartofInternational Journal of Immunogeneticsen_US
dc.titleHLA profile of the donors in the Macedonian Bone Marrow Donor Registryen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/iji.12400-
dc.identifier.urlhttps://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fiji.12400-
dc.identifier.urlhttp://onlinelibrary.wiley.com/wol1/doi/10.1111/iji.12400/fullpdf-
dc.identifier.volume45-
dc.identifier.issue6-
dc.identifier.fpage337-
dc.identifier.lpage346-
item.fulltextNo Fulltext-
item.grantfulltextnone-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
Appears in Collections:Faculty of Medicine: Journal Articles
Show simple item record

Page view(s)

145
checked on Mar 29, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.